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Pharmacology I > Reproduction I - Male > Flashcards

Reproduction I - Male Flashcards

1
Q

what do interstitial cells produce?

A

testosterone

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2
Q

what are interstitial cells stim by?

A

LH

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3
Q

what are sustentacular cells stim by?

A

FSH

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4
Q

what do sustentacular cells make?

A

inhibin

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5
Q

what are GnRH and hCG used for in males?

A

correction of cryptorchidism
determination of any remnants of testicular tissue in castrated dog/cat

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6
Q

when must GnRH and hCG be administered in a cryptorchid male?

A

within first 8 weeks of life

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7
Q

what are the main considerations/cautions to inform owners of regarding use of GnRH and hCG for cryptorchid animals?

A

there’s NO certainty that this Tx will reduce risk of sertoli cell tumors or rescue fertility

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8
Q

what hormones control testicular descent?

A

IGF3
AMH
androgen (testosterone)

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9
Q

GnRH indication in males

A

correct cryptorchidism

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10
Q

GnRH administration

A

IM, since digested in GI

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11
Q

GnRH adverse effects

A

NONE
since naturally occurring

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12
Q

Deslorelin indications

A

untested for correcting cryptorchidism

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13
Q

Deslorelin is a ___ analog

A

GnRH

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14
Q

hCG indications in male

A

correct cryptorchidism

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15
Q

hCG administration

A

IM

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16
Q

hCG is distributed to…

A

testes and ovaries

17
Q

hCG adverse effects

A

hypersensitivity

18
Q

what is benign prostatic hyperplasia (BPH)?

A

enlarged prostate in breeder dogs

19
Q

describe the growth process of benign prostatic hyperplasia (BPH)

A

testosterone + 5a-reductase -> 5a-dihydrotestosterone
causes enlargement

20
Q

Finasteride indications

A

Tx/Prevent benign prostatic hyperplasia (BPH)
*induces prostate involution by apoptosis of hyperplastic cells

21
Q

how does Finasteride Tx/prevent benign prostatic hyperplasia (BPH)?

A

blocks 5a-reductase
prevents testosterone conversion to 5a-dihydrotestosterone

22
Q

Finasteride is a ___ acting drug

A

long acting
effects take long time

23
Q

Finasteride may interact with…

A

anticholinergic (atropine)

24
Q

Finasteride Tx has a __% chance of recurrence for benign prostatic hyperplasia (BPH)

A

45%
**best thing to do would just be neuter

25
Q

Medroxyprogesterone acetate indications

A

ELDU
Tx/Prevent benign prostatic hyperplasia (BPH) in breeding dogs

26
Q

Medroxyprogesterone acetate is derived from…

A

progesterone

27
Q

how does Medroxyprogesterone acetate Tx/Prevent benign prostatic hyperplasia (BPH) in breeding dogs?

A

directly competes with active testosterone aka 5a-dihydrotestosterone

28
Q

Medroxyprogesterone acetate adverse effects

A

increase BW
lethargy
behavior change (aggressive)
adrenocortical depression
diabetes
hypothyroid
***temporary inhibits spermatogenesis (so NOT DOC)

29
Q

Medroxyprogesterone acetate contraindications

A

pregnancy since increased risk of fetal abnormality and mammary/uterine neoplasia

Pharmacology I (11 decks)

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