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Pharmacology I > Corticosteroids (Never Finished oopsie) > Flashcards

Corticosteroids (Never Finished oopsie) Flashcards

1
Q

list the adrenal layers from cortex (outside) to medulla (inside)

A

zona glomerulosa
zona fasciculata
zona reticularis

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2
Q

what’s produced by zona glomerulosa?

A

aldosterone aka mineralcorticoids

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3
Q

what’s produced by zona fasciculata?

A

cortisol aka glucocorticoids

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4
Q

what’s produced by zona reticularis?

A

androgens

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5
Q

release of cortisol and aldosterone from adrenal is stim by what?

A

ACTH

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6
Q

hypoadrenocorticism aka Addison’s is very common in…

A

dogs

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7
Q

hypoadrenocorticism aka Addison’s pathology

A

iatrogenic (via overdose of Tx hyper)
neoplastic (pituitary tumor that destroys ACTH production)
***primary autoimmune disorder
breed predisposed (poodle, water dog, nova scotia duck retriever)

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8
Q

hypoadrenocorticism aka Addison’s diagnostics

A

CHEM - hyperkalemia, hyponatremia, hypochloremia (pt will be PU/PD)
***ACTH stim test

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9
Q

describe the ACTH stim test for hypoadrenocorticism aka Addison’s

A

decreased CORT at the start
ACTH will NOT induce response

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10
Q

Hydrocortisone is ___ form of cortisol

A

endogenous

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11
Q

Hydrocortisone glucocort:mineralcort ratio

A

1 to 1

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12
Q

Hydrocortisone administration

A

IV
**can use to save dog from Addison’s crisis

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13
Q

list the hypoadrenocorticism drugs that are ONLY glucocorticoids potency

A

Triamcinolone
Dexamethasone

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14
Q

what hypoadrenocorticism drug is the most potent glucocorticoid?

A

Dexamethasone

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15
Q

what is the most potent mineralcorticoid for Tx hypoadrenocorticism?

A

Aldosterone

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16
Q

Desoxycorticosterone Pivalate administration

A

depot drug

17
Q

Desoxycorticosterone Pivalate duration of effect

A

21-30 days

18
Q

what are the two main drugs used during an Addisonian crisis? why?

A

Hydrocortisone
Dexamethasone
**both gievn IV

19
Q

list all the drugs for Tx hypoadrenocorticism that are more glucocorticoid than they are miceralcorticoid

A

Prednisone
Methylprednisolone
Triamcinolone
Dexamethasone

20
Q

list all the drugs for Tx hypoadrenocorticism that are more miceralcorticoid than they are glucocorticoid

A

Fludrocortisone
Desoxycorticosterone Pivilate
Aldosterone

21
Q

what are the two most common drugs to send home with pt for Tx hypoadrenocorticism?

A

Flurdrocortisone
Prednisone

22
Q

Prednisone contraindications

A

being a cat - since they poorly metabolize
liver failure

23
Q

describe glucocorticoid dosing as physiologic replacement, anti-inflammatory, and immune suppression

24
Q

how do glucocorticoids work for osteoarthritis (OA)?

Pharmacology I (11 decks)

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