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Pharm 2 > repro / womens health (exam 2) > Flashcards

repro / womens health (exam 2) Flashcards

1
Q

what are the 2 primary repro hormones in women?

A

estrogen and progesterone

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2
Q

where are estrogen and progesterone made?

A

mostly ovaries, also adrenal cortex

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3
Q

what are estrogen nd progesterone synthesized by?

A

cholesterol

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4
Q

what are the 3 ovarian estrogens?

A

-estradiol
-estrone
-estriol

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5
Q

when you’re __________, progesterone si secreted by corpus leutem last half of cycle

A

not pregnant

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6
Q

when you’re _____, progesterone maintains pregnancy and prepares for lactation

A

pregnant

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7
Q

days 1-14 of menstrual cycle = ____ phase

A

follicular

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8
Q

days 15-28 of menstrual cycle are the _____ phase

A

luteal

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9
Q

what are extreme PMS symptoms?

A

premenstrual dysphoric disorder (PMDD)

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10
Q

what is characterized by chronic pelvis pain and is a common GYN problem

A

endometriosis

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11
Q

what anti-depressants are used for PMS/PMDD

A

SSRIs or SNRIs

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12
Q

what is the first line treatments for PMS/PMDD

A

anti-depressants

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13
Q

what is the second-line therapy for PMS/PMDD

A

oral contraceptives (progestins)

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14
Q

what is the treatment of PMS/PMDD if the symptoms are anxiety / insomnia?

A

benzodiazepines (alprazolam)

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15
Q

what kinds of meds are used to manage symptoms of endometriosis

A

-NSAIDS
-hormonal contraceptives
-GnRH agonists

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16
Q

what is the drug therapy for menopause?

A

hormone replacement therapy (estrogen)

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17
Q

example of hormone replacement estrogen in women

A

conjugated estrogen

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18
Q

pharmacokinetics of conjugated estrogen?

A

oral = slow release
patch = avoid first-pass

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19
Q

what are the actions of estrogens?

A

-circulate to target cell (ovary)
-affects primarily the reproductive system

20
Q

what are uses of estrogens?

A

-birth control
-menopause
-replacement therapy
-slow bone loss in osteoporosis
-palliative care for breast cancer / prostate cancer

21
Q

what are adverse effects of of estrogens?

A

-thromboembolic conditions

22
Q

what are black box warnings of estrogens?

A

-cancer
-clots
-dementia

23
Q

what are contraindications of estrogens?

A

-thromboembolic disorders
-CV disease
-tobacco use
-hx. of breast/repro cancer

24
Q

what is sued to prevent hyperplasia of the endometrial lining

A

progestins

25
Q

what is our example progestin?

A

medroxyprogesterone acetate

26
Q

routes of administration for medroxyprogesterone acetate?

A

oral, IM, topical

27
Q

what med acts on endometrial lining to suppress pituitary hormones to inhibit ovulation

A

progestins

28
Q

what med prevents spontaneous uterine contraction

A

progestins

29
Q

what are uses of progestins?

A

-contraceptives
-treat amenorrhea and uterine bleeding
-fertility programs
-oncology
-plan B

30
Q

adverse effects of progestins?

A

-CV comp.
-Thromboembolic conditions

31
Q

black box warnings of progestins

A

-pregnancy
-CV
-thromboembolic
-dementia

32
Q

contraindications of progestins?

A

preg/lac
CV disease
thromboembolic disorder

33
Q

nursing implications of estrogens and progestins

A

-identify high risk women (medical history, vitals, weight, weight, mammo)
-patch may be applied weekly or bi-weekly

34
Q

education of estrogen and progestins

A

-monitor weight
-smoking cessation
-report vaginal bleeding
-teach signs of thromboembolism

35
Q

why are estrogen-progestin combos used?

A

smaller doses of both instead on 1 large does decreases symptoms

36
Q

example of estrogen-progestin combination drug

A

conjugated estrogen-medroxyprogesterone

37
Q

what are admin routes of est-progestin combos?

A

PO, IM, implant, IUD

38
Q

how does the estrogen part of combo drugs prevent pregnancy?

A

-inhibit ovulation
-suppress FSH/LH
-stabilize endometrium

39
Q

how does the progestin part of combo drugs prevent pregnancy?

A

-thin endometrium
-slow sperm transport
-thicken cervical mucous
-suppress LH surge

40
Q

uses of estrogen/progestin combos

A

-contraception
-treatment of PMS/PMDD
-HRT

41
Q

adverse effects of estrogen-progestin combos?

A

-CV complications
-thromboembolic conditions
-irregular vag bleeding

42
Q

what are black box warnings for estrogen-progestin combos

A

-smoking
-osteoporosis
-thromboembolic events

43
Q

contraindications of estrogen-progestin combos

A

-smoking
-women older than 35
-hx of thromboembolic probs

44
Q

nurse prescribes estrogen replacement therapy to relieve severe menopausal symptoms of hot flashes, which are a result of…
-insufficient gonadotropin secretion
-vasomotor instability
-high estrogen levels
-decreased progesterone

A

vasomotor instability

45
Q

after teaching ab warning signs associated with combo hormonal contraception, what statement results in additional education
-breakthrough bleeding is sign of uterine abnormality
-i should go to ER if i get sudden, severe HA that is not relieved with analgesic
-severe leg pain / swelling should immediately be reported
-CV probs are most severe adverse effects associated with oral contraceptives

A

-breakthrough bleeding is sign of uterine abnormality

-its an adverse effect

Pharm 2 (10 decks)

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