drugs for migraines (exam 3) Flashcards
what are causes of migraines?
-neurogenic vasodilation
-genetics
-in women more than men
which migraine med stimulates vascular smooth muscle to CONSTRICT cranial blood vessels?
ergotamine tartrate
what are adverse effects of ergotamine tartrate?
CV effects
musculoskeletal effects (cyanosis, n/t)
vertigo
n/v
what are contraindications of ergotamine tartrate
vascular disease
azole antifungals and macrolide antibiotics
which migraine med produces cranial vascular constriction. also relieves nausea, vomiting, and photophobia
sumatriptan
what are adverse effects of sumatriptan
dizzy
anxiety
malaise
what are contraindications of sumatriptan
vascular disease
what are the multiple routes of sumatriptan admin.
SQ, SL, PO, nasal
sumatriptan may take up to ____ to work
2 hours
which beta-adrenergic blocker can prevent migrianes
propanolol
which calcium channel blocker can help prevent migraines?
verapamil
which carboxylic acid derivative can help prevent migraines?
valporic acid
which GABA can help prevent migraines?
gabapentin
which ACE1 inhibitor can help prevent migraines?
enalapril
which tricyclic antidepressant can help prevent migraines?
imipramide
