Repairing Strand Breaks

Question 1

BER, NER, and MMR are all strand specific ____ repairing system

Answer 1

Single-Strand breaks (SSBs)

Question 2

2 mechanisms that the cell attempts to repair a complete break in DNA molecule

Answer 2

Direct Joining
Homologous Recombination

Question 3

This requires proteins that recognize and bind to the exposed ends and bring them together for ligating.

Answer 3

Direct Joining

Question 4

They would prefer to see some complementary nucleotides but can proceed without them so this type of joining is also called

Answer 4

Non-homologous end joining (NHEJ)

Question 5

Two of the proteins used in homologous recombination are encoded by the genes: _____ & _______ (double stranded DNA break). Inherited mutations in these genes predispose women to breast and ovarian cancers

Answer 5

BRCA1 & BRCA2

Question 6

Sister chromatic (available in G2 after chromosome duplication), or
homologous chromosome (in G1; that is, before each chromosome has been duplicated)

Answer 6

Homologous recombination

Question 7

Homologous recombination

Answer 7

aka as Homology-directed repair (HDR)

Question 8

Cell cycle controls/regulations

Answer 8

G1
G2
Metaphase

ALL checkpoints