Cancer....

Question 1

a gene which in certain circumstances can transform a cell into a tumor cell.

Answer 1

Oncogene

Question 2

_________ mutations are usually a gain of function and dominant

Answer 2

Oncogene

Question 3

_______ genes normally arrest cell division

Answer 3

Tumor Suppressor

Question 4

______ _______ gene mutations are usually a loss of function and recessive

Answer 4

Tumor suppressor

Question 5

Proto-oncogenes have italicized

Answer 5

3 letter designations (ras)

Question 6

An oncogene that occurs within a virus has the prefix

Answer 6

“v”

Question 7

An oncogene that occurs within a cell has the prefix

Answer 7

‘c’

Question 8

Breast cancer

Answer 8

Oncogene - sis (platelet derived growth factor)

Question 9

Breast Cancer

Answer 9

Her-2/neu (protein kinase)

Question 10

Chronic Myeloid Leukemia

Answer 10

abl - Tyrosine kinase

Question 11

Many cancers

Answer 11

N-ras – Signal transduction

Question 12

Burkitt’s Lymphoma

Answer 12

c-myc – nuclear protein, initiate cell cycle

Question 13

Growth factors
Growth factor receptors
G proteins and intracellular kinases
Cell cycle control proteins (cyclin/Cdk)
Apoptosis control protein
Transcription factors

Answer 13

Types of proteins encoded by oncogenes

Question 14

promotes RNA synth; in nucleus

Answer 14

Transcription factors

Question 15

Growth factors

Answer 15

step 1

Question 16

growth factor receptors (EGF receptor)

Answer 16

step 2

Question 17

Protein kinases or proteins that activate protein kinases (cyclin-cdk)

Answer 17

step 3

Question 18

Proteins that control the cell cycle (Cyclin D – bcl-1)

Answer 18

Step 4

Question 19

Proteins that affect apoptosis

Answer 19

step 5

Question 20

____ is in many cancers

Answer 20

N-ras

Question 21

analog of GF receptor (receptor always active)

Answer 21

Her-2/nue

Question 22

HER2 does not need any triggers, it is ____ triggering

Answer 22

self

Question 23

anti-onco genes

Answer 23

tumor suppressor genes

Question 24

Tumor suppressor genes code for proteins that regulate cell-cycle progression and hold cell in ______ or induce ________

Answer 24

quiescence; apoptosis

Question 25

Retinoblastoma
P53

Answer 25

Most commonly used Tumor Suppressor genes

Question 26

Found in 50% of cancer cases

Answer 26

P53

Question 27

Colon, breast, and lung cancer

Answer 27

P53

Question 28

Retinoblastoma, osteosarcoma, small-cell lung cancer

Answer 28

Rb

Question 29

Transcription Factors (MYC)

Answer 29

Step 6