HPV types

Question 1

E1: Viral replication
E2: transcriptional regulation
E4: disrupts cytokeratins
E5: interacts with growth factor receptors
E6: transforming protein; causes p53 degradation
E7: transforming protein; interferes with Rb binding

Answer 1

Early genes of HPV

Question 2

transforming protein; causes p53 degradation

Answer 2

E6

Question 3

transforming protein; interferes with Rb binding

Answer 3

E7

Question 4

P53 and Rb are both ___ _____ _____

Answer 4

tumor suppressing genes

Question 5

___ & ____and are both tumor suppressing genes

Answer 5

P53 & Rb

Question 6

___ being largely responsible for driving cell proliferation

Answer 6

E7

Question 7

___ enhances cell survival

Answer 7

E6

Question 8

The combination of E6 and E7 is a very potent inducer of _______ __________

Answer 8

keratinocyte immortalization