Renin Inhibitors

Question 1

Example of Renin Inhibitor

Answer 1

Aliskiren

Question 2

MOA of Renin Inhibitor

Answer 2

Inhibit renin directly ( renin convert Angiotensinogen to Angiotensin 1)

Question 3

Indication of Renin Inhibitor

Answer 3

Tx of hypertension alone or in combination with other antihypertensive

Question 4

Interaction between Aliskiren and ACE inhibitors

Answer 4

Should not be given together due to increased risk of hyperkalaemia, hypotension or renal impairment compared to a single drug

Question 5

What’s the dose of Aliskiren in essential hypertension

Answer 5

150mg OD , increased if necessary to 300mg OD