Antifungal

Question 1

Types of antifungal

Answer 1

Triazole
Imidazole
Other

Question 2

Triazoles antifungal is used to tx

Answer 2

Prevention and systemic tx of fungal infections

Question 3

List examples of triazole abx

Answer 3

Fluconazole, itraconazole, posaconazole, voriconazole

Question 4

Imidazole abx is used to tx?

Answer 4

Vaginal candidasis and dermatophyte infections

Question 5

Eg of imidazole

Answer 5

Clotrimazole, econazole , Ketoconazole
Miconazole

Question 6

Miconazole is used to tx

Answer 6

Oral and intestinal infections
Cause significant drug interaction warfarin

Question 7

Examples of polyene antifungal

Answer 7

Nystatin and amphotericin

Question 8

Examples of polyene antifungal

Answer 8

Oral, orophargngeal, perioral infections, candida alibicans infection of skin

Question 9

What is amphotericin IV infusion used to tx( polyene )

Answer 9

System infections .
Active against most fungi and yeast
Toxic when given parenterally ( avoid rapid infusion) with side effects

Question 10

Facts about other antifungal s

Answer 10

Eg Griseofulvin and terbinafine

Question 11

Whats the drug of choice for fungal nail infection

Answer 11

Terbinafine

Question 12

Other indication of terbinafine

Answer 12

Used for ringworm infection where oral tx is inappropriate

Question 13

Caution with amphotericin B

Answer 13

Avoid rapid infusion (risk of Arrhythmia)
Anaphylaxis can occur with IV(test dose advised)

Question 14

MHRA warning for amphotericin B

Answer 14

Different forms are not interchangeable as it has led to fatal overdoses
Prescribers should specify formulation

Question 15

Is amphotericin B safe in pregnancy?

Answer 15

Not known to be harmful but manufacturers advise against

Question 16

Monitoring requirements with amphotericin B

Answer 16

Plasma electrolytes, blood counts, hepatic and renal function

Question 17

Caution with fluconazole

Answer 17

Susceptibility to QT interval prolongation

Question 18

Side effect of Fluconazole

Answer 18

Diarrhoea, GI, N, V and skin reactions

Question 19

State when to discontinue fluconazole

Answer 19

If rash occurs or sign of hepatic disease

Question 20

What age can fluconazole be sold OTC?

Answer 20

Exception to legal category
Capsules sold to public for vaginal candidiasis and candida balancing
Age 16-60yrs

Question 21

Pack size of fluconazole sold to the public

Answer 21

Not greater than 150mg and labelled to show max dose of 150mg

Question 22

Important safety info for Itraconazole

Answer 22

Can cause HF
Caution with pts at risk of heart failure

Question 23

State when to seek medical attention for pts on ITRACONAZOLE

Answer 23

If signs of liver disorder occurs such as N, V, Anorexia, dark urine , abdominal pain