Renal Pathology 2 Flashcards
What is the pathogenesis of Anti-GBM Glomerulonephritis?
Circulating Abs acting of Type 4 collagen.
Discuss the morphology of Anti-GBM glomerulonephritis?
- Kidney appears grossly pale and large
2. Crescents made of parietal epithelium in Bowmans capsule.
How is Anti-GBM glomerulonephritis treated?
Plasmapheresis
Discuss Chronic glomerulonephritis
- Kidneys are small
2. Thin cortex and tubular atrophy
What are the 6 classes of lupus nephritis?
Minimal Mesangial, Mesangial Proliferative, Focal, Diffuse, Membranous, and Advanced Sclerosing
Discuss mesangial proliferative LN
- Mild to moderate hypercellularity of mesangial matrix.
- Immune complexes in mesangium
- Asymptomatic hematuria
Discuss Focal Ln
- Proliferation of endothelial and mesangial cells
- Infiltration by neutrophils
- Fibrinoid deposits in capillary loops.
Discuss Membranous Ln
Thickening of BM, severe proteinuria
Describe the glomerular lesions of Diabetic Nephropathy
Nodular glomerulosclerosis; Oval deposits of matrix in mesangial core of peripheral tubules
Discuss Amyloidosis
- Disorder of protein misfolding.
- Kidney appears grey, firm and wavy grossly.
- Ends in renal failure
What are the 2 hypertensive Renal Vascular Diseases?
Arterionephroscelrosis and Malignant Hypertension
What is the pathogenesis of Arterionephroscelrosis?
Thickening of media and intima of arterioles and small arteries with hyaline deposition on the walls.
What is the Gross morphology of Arterionephroscelrosis?
Cortex of kidney is granular; grain leather
What is the histopathology of Arterionephrosclerosis?
Homogenous pink material in vessel walls
What is the clinical feature of Arterionephroscelrosis?
Associated with Chronic essential hypertension
