Anti-microbials

Question 1

What is the MOA of Penicillins?

Answer 1

Inhibit cell wall synthesis

Question 2

What is the MOA of Bactrim?

Answer 2

Inhibit folate metabolism

Sulfa: Inhibts PABA incorporation
TMP: Inhibits DHFR

Question 3

Side effects of Bactrim?

Answer 3

Megaloblastic anemia, thrombocytopenia

Avoid in pregnancy

Question 4

Clinical uses of Bactrim

Answer 4

1. Uncomplicated UTI

2. Prostatitis

Question 5

What is the MOA of Aminoglycosides?

Answer 5

Alter protein synthesis of 30S ribosome; Bactericidal

Gentamicin and Amikacin

Question 6

Which organisms does aminoglycosides work well against?

Answer 6

Pseudomonas and Klebsiella

Question 7

Side effects of Aminoglycosides?

Answer 7

Nephrotoxicity, Ototoxicity

Question 8

What is the MOA of Nitrofurantoin?

Answer 8

Bacteria reduce it to DNA-damaging compound.

Question 9

Side effects of Nitrofurantoin

Answer 9

N/V/D and brown urine

Question 10

What kind of bacteria is metronidazole good against?

Answer 10

Anaerobic bacteria

Question 11

Side effects of Metronidazole

Answer 11

Metallic taste, disulfiram rxn with alcohol

Question 12

Name specific bacteria metronidazole is used against?

Answer 12

1. Trichomonas

2. Giardia

Question 13

What is the MOA of Quinolones? Side effects?

Answer 13

Interferes with DNA gyrase and topoisomerase; Bactericidal

-floxacin
SE: Ruptured tendon, contraidicated in pregnancy

Question 14

Which drug is BEST against Pseudomonas?

Answer 14

Ciprofloxacin

Question 15

Which drug is ineffective against UTIs?

Answer 15

Moxifloxacin