Renal Pathology 1 Flashcards
Discuss the Morphology of Minimal Change Disease.
Diffuse and uniform effacement of podocyte foot processes.
- Normal GBM
- Vacuoles in podocyte cytoplasm.
What are the clinical features of Minimal Change Disease?
- Selective Proteinuria
2. No hematuria
How is Minimal Change Disease treated?
Corticosteroids
Discuss the Focal Segmental Glomeruloscelrosis.
- Increased mesangial matirx.
- IgM in areas of sclerosis
- Collapse of glomerular tufts
What are the clinical features of Focal Segmental Glomeruloscelrosis?
Hypertension, hematuria, Decreased GFR
What is the pathogenensis of Membranous Nephropathy?
Immune complexes with little inflammation.
Discuss the morphology of membranous nephropathy
- Enlarged glomeruli
2. Spike and dome appearance
Discuss the morphology of Membranoproliferative glomerulonephritis.
- Tram track apperance to basement membrane.
2. Enlarged/hypercellular glomeruli
Discuss the clinical features of MPGN
Can present with both nephrotic and nephritic syndrome.
Describe the pathogenesis of Acute proliferative glomerulonephritis
Immune complex mediated caused by a streptococcal protein
Discuss the morphology of Acute proliferative glomerulonephritis
- Capillary lumen obliterated.
2. Subepithelial humps
What are the clinical features of acute proliferative glomerulonephritis.
- Abrupt onset of nephrotic syndrome
2. Hematuria
What is the Pathogenesis of IgA Nephropathy (Berger’s Disease)
Abnormal production of IgA. Antibodies are glycosylated and not cleared and trapped in mesangium.
Discuss the morphology of IgA Nephropathy
C3 and IgA in staining of mesangium
What are the clinical features of IgA Nephropathy?
Presents with hematuria and Henoch-Schonlein Purpura. Purple skin lesions and abdominal symptoms
