Renal: Fluid Management and Renal Filtration

Question 1

what is the pathway through the nephron?

Answer 1

glomerulus – space of Bowman’s capsule – proximal convoluted tubule – descending loop of Henle, ascending loop of Henle – distal convoluted tubule – collecting duct

Question 2

what is GFR?

Answer 2

glomerular filtration rate

Question 3

what is hydrostatic pressure in Bowman’s capsule?

Answer 3

afferent tubule coming into the glomerulus with high hydrostatic pressure – fluid being pulled out of the capillary

Question 4

what is oncotic pressure in Bowman’s capsule?

Answer 4

high amounts of solutes left in the capillary, pulling fluid in to balance out

Question 5

what happens to glomerular filtration rate with an increased BP?

Answer 5

increases

Question 6

how do overuse of NSAIDs cause kidney injury?

Answer 6

prostaglandins cause vasodilation in the kidneys
NSAIDs block prostaglandin production which can lead to decreased blood flow to the kidneys

Question 7

where does filtration occur in the kidneys? what kinds of particles are filtered?

Answer 7

glomerulus – only small molecules make it through