Regulation Of Calcium And Phosphate Flashcards
Recommended intake of calcium
Approx 1000mg a day
Most abundant metal in the body and the diet should meet all the requirements
Foods rich in calcium
Tahini
Dairy
Fish
Broccoli
Where does most of the calcium reside in the body
In skeleton and teeth as calcium hydroxyapatite crystals
Total body calcium
Skeleton : 99%
Intracellular : 1%
Extra cellular ;0.1%
Extra cellular calcium
Tight regulated . Can be ionised (45%) or bound . Unbound ionised calcium is the biologically active component.
Bound calcium
Can be as plasma proteins such as albumin (45%) or anions ( bicarbonate, phosphate, lactate)
Hormonal control of INCREASE in serum calcium and phosphate
Parathyroid hormone ( PTH) secreted by the parathyroid glands Vitamin D - synthesised in skin or intake via diet Main regulators of calcium and phosphate homeostasis via actions on kidney bone and gut
Hormonal DECREASE of serum calcium and phosphate
Calcitonin ( secreted by thyroid parafollicular cells )
Can reduce calcium acutely but no negative effect of parafollicular cells are removed ( e.g. thyroid echo my)
Sources of vitamin D
Vitamin D2 from diet ( ergocalciferol)
Vitamin D3 from sunshine ( synthesis happens in skin) - cholecalciferol
Vitamin D 3 synthesis
UVB - 7-dehydrocholesterol - pre- vitamin D3 - vitamin D3 - hydroxylation by 25 Hydroxylase - 25(OH)cholecalciferol - hydroxylation by 1 alpha Hydroxylase - 1,25(OH)2cholecalciferol
What is a good indicator of calciferol in body
Serum 25-OH cholecalciferol as active form of vitamin D is quite unstable
Negative feedback in vitamin D metabolism
Calcitriol regulates its own synthesis by decreasing transcription of 1 alpha Hydroxylase
Effects of calcitriol
On bone ; calcium reabsorption
Gut ; calcium absorption and phosphate absorption from food
Kidneys ; increased calcium and phosphate reabsorption
Parathyroid hormone
Released by chief cells in parathyroid glands
Secreted as large precursor ( pre pro PTH) and cleaved to PTH ( active hormone )
G protein coupled calcium sensing receptor on chief cells detect change in circulating calcium conc
PTH secretion inversely proportional to serum calcium
Calcium sensing receptors on chief cells ( high )
High EcF ( Calcium )
Calcium binds to receptors on parathyroid cells
PTH secretion is inhibited