Red cell antibodies in pregnancy GTG

Question 1

When should blood group and antibody status be checked?

Answer 1

At booking and 28w

Question 2

What are the implications of maternal red cell antibodies?

Answer 2

Severe fetal anaemia resulting in hydrops and worsening perinatal outcome

Question 3

Non-invasive genotyping with maternal blood as possible for which antigens?

Answer 3

D, C, c, E, e, K

Question 4

What titres give a risk of severe haemolytic disease of the fetus/newborn?

Answer 4

anti-D >15iu/ml
anti-c >20iu/ml
anti-K any titres
anti-E and anti-c together

Question 5

When should antibody levels be monitored during pregnancy?

Answer 5

<28w - every 4 weeks
>28w - every 2 weeks until delivery

Question 6

What titres give a moderate risk of severe haemolytic disease of the newborn?

Answer 6

anti-D 4-15iu/ml
anti-c 7-20iu/ml

Question 7

How does anti-c affect neonate

Answer 7

late anaemia

Question 8

How does anti-D affect neonate

Answer 8

early jaundice

Question 9

How does anti-K affect neonate

Answer 9

early anaemia