Lynch syndrome TOG

Question 1

Inheritance of lynch syndrome

Answer 1

Autosomal dominant

Question 2

Main cancers cause by Lynch?

Answer 2

Colon, endometrial

Question 3

Other cancers caused by Lynch?

Answer 3

Ovary, breast, bladder, stomach, pancreas, kidney, brain

Question 4

Cause of lynch syndrome?

Answer 4

Mutation in mismatch repair genes
(MLH1, MSH2, MSH6, PMS2)

Question 5

What interventions can be considered to reduce cancer risk in Lynch patients?

Answer 5

Lifestyle - stop smoking, reduce weight, exercise, diet
COCP/mirena IUS - reduces endometrial proliferation
Aspirin
Hysterectomy if family complete

Question 6

What % of endometrial cancers are caused by Lynch syndrome?

Answer 6

3%

Question 7

When would you get screened for lynch?

Answer 7

After a diagnosis of colon or endometrial ca

Question 8

What sort of surveillance do Lynch patients get?

Answer 8

Colonoscopy every 2 years
TVUS and endometrial biopsy every 1-2 years but poor evidence

Question 9

When can preventative TAH +/- BSO be offered?

Answer 9

40+ years, family complete

Question 10

What is known to reduce cancer risk in lynch patients?

Answer 10

Aspirin