Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathology 2 > Red Blood Cells And Bleeding Disorders > Flashcards

Red Blood Cells And Bleeding Disorders Flashcards

0
Q

Average content (mass) of hemoglobin per red cell expressed in picograms

A

Mean Cell Hemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Average volume of a red cell expressed in femtoliters

A

Mean Cell Volume

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Average concentration of hemoglobin in a given volume of packed red cells expressed in grams per deciliter

A

Mean Cell Hemoglobin Concentration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Coefficient of variation of red cell volume

A

Red Cell Distribution Width

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Inc RDW

Dec RDW

A

Iron deficiency

Thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Hemolytic Anemias

A 
Hereditary spherocytosis
G6PD deficiency
Sickle cell anemia
Thalassemia
Autoimmune HA
Microangiopathic HA
Macroangiopathic HA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Mutations of ankyrin, spectrin, band 3 and band 4.2

A

Hereditary spherocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Hemolytic anemia
Aplastic crisis
Hemolytic crisis

A

Parvovirus B19

EBV mononucleosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Small dark nuclear remnants present in RBCs of asplenic patients

A

Howell Jolly bodies

Hereditary spherocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Symptoms of extravascular hemolysis

A

Anemia
Splenomegaly
Jaundice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Symptoms of intravascular hemolysis

A 
Anemia
Hemoglobinemia
Hemoglobinuria
Hemosiderinuria
Jaundice
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Episodic hemolysis

A

G6PD deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Triggers of G6PD deficiency

A

INFECTIONS
Drugs antimalarials sulfonamides
Fava beans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Membrane bound precipitates on denatured globin chains

A

Heinz bodies

G6PD def

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

RBCs with damaged membranes removed by splenic macrophages

A

Bite cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Recovery phase of G6PD deficiency heralded by

A

Reticulocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

6th codon of B globin: glu to val

A

Sickle cell anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

RBCs shaped like curved blades

A

Sickled cells
Sickle cell anemia

Reticulocytosis
Howell Jolly bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Trapping of sickled red s leading to splenic infarction

A

Autosplenectomy

Sickle cell anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Types of crisis in Sickle cell anemia

A

Vasoocclusive
Sequestration
Aplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q 
Chronic tissue hypoxia
Hyposthenuria - cannot concentrate urine 
Infections
Prominent cheekbones
Crewcut skull appearace
Chronic hyperbilirubinemia
A

Sickle Cell Anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Sickle cell anemia

Initial dx test

A

Periph blood smear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Sickle cell anemia

Gold std

A

Hb electrophoresis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Sickle cell anemia

DOC

A

Hydroxyurea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q 
Alpha thalassemia
1
2
3
4
A

Silent carrier state
A thalassemia trait
Hemoglobin H disease
Hydrops fetalis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Beta thalassemias
Transfusion dependence. HbF
Severe but no transfusion
Asx

A

Major cooley’s anemia
Intermedia
Minor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Dehydrated RBCs with bull’s eye appearance

A

Target cells or codocytes

Thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Basophilic stippling
Anisocytosis
Poikilocytosis
Microcytic hypochromic anemia

A

Thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Crew cut skull appearance
Chipmunk facies
Hemosiderosis
Hemochromatosis

A

Thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Treatment for hemochromatosis

A

Phlebotomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

DOC for hemochromatosis

A

Deferoxamine chelation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Leading cause of death in PNH

A

Thrombocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Warm agglutinin

Cold agglutinin

A

IgG

IgM

33
Q

Autoimmune HA seen in SLE, CLL or methyldopa

A

Warm agglutinin

34
Q

Autoimmune HA seen in Mycoplasma and mononucleosis

A

Cold agglutinin

35
Q

Anti Ig antibody added to patient’s RBCs agglutinate if RBCs are coated with Ig

A

Direct Coombs’ Test

36
Q

Normal RBCs added to serum agglutinate if serum has Ig

A

Indirect Coombs’ Test

37
Q

Damaged RBCs upon passing through obstructed or narrowed vessel lumina
Cardiac valve prosthesis

A

Microangiopathic HA

38
Q

RBCs with spikes

A

Burr cells or echinocytes

Microangiopathic HA

39
Q

Fragmented RBCs

Halved RBCs

A

Schistocytes
Helmet cells
Microangiopathic HA

40
Q

Intrinsic hemolysis

Extravascular site

A

Hereditary spherocytosis
Sickle cell anemia
Thalassemia

41
Q

Intrinsic hemolysis

Both intra and extravascular

A

G6PD deficiency

42
Q

Intrinsic hemolysis

Intravascular site

A

PNH

43
Q

Extrinsic hemolysis

Intravascular site

A

Autoimmune HA
Microangiopathic HA
Macroangiopathic HA

44
Q

Anemias of diminished erythropoiesis

A 
Megaloblastic
Pernicious
IDA
Chronic disease
Aplastic 
Pure red cell aplasia
45
Q

Macroovalocytes
Hyper segmented neutrophils
Giant metamyelocytes

A

Megaloblastic anemia

46
Q

Autoimmune gastritis resulting to failure of intrinsic factor production

A

Pernicious anemia

47
Q

Atrophy of fundic glands: chief and parietal
Gastric mucosa replaced by goblet cells
Beefy tongue
Demyelination of dorsal and lateral tracts of spinal cord

A

Intestinalization
Atrophic glossitis

Pernicious anemia

48
Q

Schilling test

A

Pernicious anemia

49
Q

Schilling test

Stage 1 normal

A

B12 deficiency

50
Q

Schilling test
Stage 1 low
Stage 2 normal

A

Pernicious anemia

51
Q

Schilling test

Both stages are low

A

Malabsorption

52
Q

Iron absorbed primarily in the

A

Proximal duodenum

53
Q

Koilonychia spoon nails
Pica
Plummer Vinson syndrome

A

IDA

54
Q

Esophageal webs
Microcytic hypochromic anemia
Atrophic glossitis

A

Plummer Vinson syndrome

55
Q

IL6 stimulates inc in _ causing reduced iron transfer from storage pool to BM

A

Hepcidin

56
Q

Inc serum iron
Low TIBC
Inc ferritin
Inc transferrin sat

A

Hemochromatosis

Thalassemia

57
Q

Low serum iron
Low TIBC
Inc ferritin

A

Chronic Disease

58
Q

Low serum iron
Inc TIBC
Low ferritin
Low transferrin salt

A

IDA

59
Q

Idiosyncratic effect of this drug is aplastic anemia

A

Chloramphenicol

60
Q

Occupational chemical exposure causes aplastic anemia

A

Benzene

61
Q

Hypocellular BM with fat cells

Hypercellular BM with fat cells

A

Aplastic anemia

Polycythemia vera

62
Q

Anemia
Thrombocytopenia
Neutropenia
Without splenomegaly

A

Aplastic anemia

63
Q

Non thrombocytopenic purpura due to increased fragility of cells

A

T

64
Q

PC<100,000

A

Thrombocytopenia

65
Q

Thrombocytopenia

A

Immune thrombocytopenic purpura

Thrombotic microangiopthies

66
Q

Most feared complication of immune thrombocytopenic purpura

A

Intracranial bleeding

67
Q

Thrombotic microangiopathies

A

Thrombotic thrombocytopenic purpura

HUS

68
Q 
Renal failure
Anemia
Thrombocytopenia
Fever
Neurologic deficit
A

Thrombotic thrombocytopenic purpura

69
Q

Renal failure
Anemia
Thrombocytopenia

A

HUS

70
Q

Platelet dysfunction

A

Bernard Soulier

Glanzmann’s thrombasthenia

71
Q

Inc bleeding time

Dec PC

A

Bernard Soulier

72
Q

Inc bleeding time

Normal PC

A

Glanzmann’s thrombasthenia

73
Q

Coagulation disorders

A

Von Willebrand
Hemophilia
DIC

74
Q

Most common inherited bleeding disorder

Treatment

A

Von Willebrand

Desmopressin

75
Q

Most common hereditary disease with life threatening bleeding

A

Hemophilia A

Factor VIII

76
Q

Christmas disease

A

Hemophilia B

Factor IX deficiency

77
Q

Most specific test for DIC

A

D dimer

78
Q

Associated with obstetrics and trauma

A

Acute DIC

79
Q

Occurs in cancer patients

N PC and clotting factors

A

Chronic DIC

Pathology 2 (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions