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Pathology 2 > Endocrine > Flashcards

Endocrine Flashcards

0
Q

Corticroph adenoma devt after surgical removal of adrenal glands

A

Nelson syndrome

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1
Q

Pituitary apoplexy triad

A

HA
Diplopia
Hypopituarism

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2
Q

Water deprivation test
CDI
NDI

A

UOsm inc >50% from baseline

<50% from baseline

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3
Q

MCC of SIADH

A

Small cell lung ca

Chlorpropramide

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4
Q

MCC pediatric hypopituitarism
Rathke’s pouch remnants
WNT

A

Craniopharyngoma

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5
Q

2 types of craniopharyngoma

A

Adamantinomatous children wet keratin lamellar

Papillary adult

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6
Q

Hypothyroidism
Children
Adult

A

Cretinism

Myxedema (Gull disease)

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7
Q

Somatotroph adenoma
Children
Adult

A

Gigantism

Acromegaly

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8
Q 
CTL4 polymorphisms
MCC hypothyroidis
Anti thyroglobulin
Anti TPO
Atrophic thyroid follicles lined by Hurthle cells
A

Hasimoto thyroiditis

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9
Q

Coxsackievirus
MCC painful thyroid gland
Multinucleate giant cells

A

Subacute De quervain thyroiditis

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10
Q

Painless thyroiditis

Postpartum

A

Lymphocytic thyroiditis

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11
Q

Woody or fibrous thyroid

A

Reidel thyroiditis

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12
Q

Diffuse thyroid hypertrophy and hyperplasia

Infiltrative ophthalmopathy

A

Graves disease

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13
Q

Multi lobulated goiter grows behind sternum and clavicles

No capsule between hyperplastic nodules and residual compressed thyroid

A

Intrathoracic or plunging goiter
Vs follicular ca

MNTG

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14
Q

Autonomous nodule in long standing goiter producing hyperthyroidism

A

Plummer syndrome

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15
Q

Follicular adenoma with oxyphilia

A

Hurthle cell adenoma

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16
Q

MC primary thyroid ca in adults
Orphan Annie
Psamomma bodies
Lymphatic

A

Papillary thyroid cancer

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17
Q

Solitary cold nodule
Dietary iodine deficiency
Bone mets

A

Follicular thyroid ca

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18
Q

Past history of well differentiated tumor
Worst prognosis
Pleomorphic giant cells mixed with sarcomatous spindle cells
Cytokeratin marker

A

Anaplastic thyroid ca

19
Q 
Parafollicular cell origin
Calcitonin
Neuroendocrine
Acellular amyloid deposits
C cell hyperplasia
A

Medullary thyroid ca

20
Q

MCC primary hyperPTH
Centrally placed nuclei
Endocrine atypia

A

Parathyroid adenoma

21
Q

Water clear cell hyperplasia

A

Primary hyperplasia

22
Q

MCC secondary hyperPTH

A

Renal failure

23
Q

MCC hypoPTH

A

Previous thyroid surgery

24
Q

Autoantibodies of T1DM

A

Anti insulin
Anti GAD
Anti ICA512

25
Q

MCC death in diabetics

A

MI

26
Q

Capillary BM thickening
Diffuse mesangial sclerosis
Nodular glomerulosclerosis

A

Kimmelstein wilson nodules

DM

27
Q

Renal papillary necrosis

A

Pyelonephritis

28
Q

MC pancreatic endocrine neoplasm

A

Insulinoma

29
Q

Whipple triad

A

Hypoglycemia sx
Low plasma glucose
Relief of sx upon glucose administration

Insulinoma

30
Q

Solitary tumors composed of giant islet cells and amyloid deposits
Islet hyperplasia

A

Nesidioblastosis

Insulinoma

31
Q

Mild DM
Necrolytic migratory erythema
Anemia

A

A cell tumors

Glucagonomas

32
Q

MCC hypercortisolism (Cushing syndrome)

A

Exogenous glucocorticoids

33
Q

Pale and homogenous pituitary gland

A

Crooke Hyaline change

Hypercortisolism

34
Q

High dose dexamethasone
Cortisol levels
ACTH levels

A

Pituitary CS low high
Adrenal CS normal low
Ectopic CS normal high

35
Q

MC sign of primary hyperaldosteronism

A

Hypertension

36
Q

Renin levels
Primary Hyperaldosteronism
Secondary

A

Dec

Inc

37
Q

Eosinophilic laminated cytoplasmic inclusions

A

Spironolactone bodies

Aldosterone producing adenomas

38
Q

MC enzyme deficiency in CAH

A

21 hydroxylase deficiency

39
Q 
Lipid depleted cells
Corticorroph hyperplasia in pituitary
Inc 17 ketosteroids 17 hydroxyprogesterone
Dec
27 hydroxycorticoids
A

CAH

40
Q

Pheochromocytoma

10

A 
Extraadrenal (parangangliomas)
B
Malignant
Not hpn
Germline mutation
41
Q

Zellballen
Salt and pepper chromatin
Chromogranin and synaptophysin neuroendocrine markers

A

Pheochromocytoma

42
Q

Parathyroid adenoma or hyperplasia
Pancreatic tumors
Pituitary tumors esp prolactinoma

A

Men 1 wermer syndrome

43
Q

Pheochromocytona
Medullary ca
Parathyroid hyperplasia

A

Men 2a sipple syndrome

44
Q

Pheochromocytoma
Medullary ca
Neuromas or ganglioneuromas

A

Men 2B

Pathology 2 (20 decks)

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