Recreational drugs Flashcards
Recreational drugs are drugs that we self administer for non-medical reasons
classes can be A<b></b>
Tolerance: where higher levels of drug required to achieve same response; due to body adapting to return to “normal” (e.g. increasing metabolism, down regulating receptors or synthesising more receptors). – need to take more and more and more
Dependence: compulsion to take drug for psychological or physical need. Evident when someone stops taking drug and experiences withdrawal symptoms. Dangerous if drug is toxic and/or shows tolerance.
recreational drugs can be categorised as stimulants and depressants what are some examples of these
stimulants (cocaine, amphetamine)
depressants (alcohol, cannabis, opioids)
Stimulants enhance excitatory synaptic transmission and depressants enhance inhibitory synaptic transmission
cocaine is a CNS stimulant what does it do
it inhibits monoamine reuptake by blocking transporter proteins therefore increasing the levels of dopamine, serotonin, adrenaline and noradrenaline in the synaptic cleft
bind to inactivates
sided effects including cocaine
tachycardia
vasoconstriction
hypertension
agitation
Amphetamines – MDMA and crystal meth
what do they usually treat
CNS stimulants: causes increased release of monoamines (dopamine and noradrenaline)
ADHD and narcolepsy
side effects of amphetamine
increased temperature, agitation, rapid breathing, dehydration, urinary retention, tachycardia, hypertension, insomnia. Long term: psychosis, anxiety, depression, cognitive impairment
opioid analgesics reduce neurotrasnittre release leasing to what
repriaotry depression dn dependence and k receptor is hallucinogenic effects.
constipation is another side effect of opioid use
cannabis
Active component is (−)-trans-Δ⁹- tetrahydrocannabinol (THC)
inhibits neurotransmitter release
depressant and psychotomimetic
when can cannabis used
treatment resistant epilepsy, (chemo induced) nausea, (chronic) pain and (MS) spasticity.
treatment fro recreational drugs
Deterrents: Antabuse (disulfiram) is used for treating alcoholism and works by inhibiting acetaldehyde dehydrogenase, giving patient severe hangover symptoms immediately after consuming alcohol.
Substitutes: Methadone or buprenorphine are morphine analogues used as safer substitutes for opioids.
Reward suppressants: Naltrexone is an opioid antagonist used for treating opioid and alcohol addiction. Baclofen is a GABAB agonist known to help treat cocaine addiction.
what drug do you to treat opioidd receptor antagonist to treat induced constipation
Naldemedine is an opioid receptor antagonist used to treat opioid induced constipation.
morphien analogies can act as a substitute for opioids what are they
Methadone or buprenorphine
what can you use to treat alcoholism
Antabuse (disulfiram) is used for treating alcoholism and works by inhibiting acetaldehyde dehydrogenase, giving patient severe hangover symptoms immediately after consuming alcohol.
what can you use to treat a cocaine addiction
baclofen as it is a a GABAb agonist
