anatomy of neurodegenerative disease Flashcards
1
Q
alzeiherms two major features
A
- Beta-amyloid plaques
2. Neurofibrillary tangles with deposits of hyperphosphorylated tau protein
2
Q
huntigntons disease sx
A
Chorea , dystonia, loss of postural reflexes
Give rise to osteoporosis , skeletal muscle problem and weakness due to mitochondria, thyroid disease
3
Q
what repeat in huntigntons
A
CAG tri nucleotide repeat
4
Q
multiple system atrophy what sign
A
hot cross bun signs of pons on MRI Parkinsonism Autonomic failure Cerebral degeneration Pyramidal signs Sighs and sleep apnoea – due to involvement of brainstem
