Receptors (G-protein coupled receptors)

Question 1

What are the sympathetic receptors?

Answer 1

Alpha 1 and 2 and Beta 1 and 2

Question 2

What are the Parasympathetic Receptors?

Answer 2

M1, M2, M3

Question 3

What is the major function of alpha 1

Answer 3

Vascular smooth muscle contraction, Pupillary dilation, Intestinal and bladder sphincter contraction

Dilates veins and eyes, contracts butthole and peehole

Question 4

Major FUnction of alpha 2

Answer 4

Lowers sympathetic outflow
Lowers insulin release
Lowers lipolysis
enhances platelet agg
Lowers

Question 5

Major function of Beta 1

Answer 5

High heart rate and high contractility

Also Renin release and lipolysis

Question 6

Major Function of Beta 2

Answer 6

Vasodilation, Bronchodilation, Increased heart rate, increased heart contractility, increased lipolysis, in creased insulin release, increased aqueous humor

decreased uterine tone,

Question 7

Major Function of Muscarinic 1

Answer 7

enteric nervous system

Question 8

Major function of M2

Answer 8

Lowers heart rate, contraction of atria

Question 9

Major function of M3

Answer 9

Increased secretions (tears, stomach, lungs), gut peristalsis, bladder contraction, BRONCHOCONSTRICTION (so cholinomimetics can make asthma worse), pupillary sphincter muscle contraction

Question 10

D1 receptor function

Answer 10

Relaxes vascular smooth muscle

Question 11

D2 receptor function

Answer 11

modulates transmitter release

Question 12

Major function of H1

Answer 12

Nasal and bronchial mucous production, pruritis, pain, bronchiole contraction

Question 13

Major Function of H2

Answer 13

increase gastric acid secretion

Question 14

V1 receptor major function

Answer 14

vasopressin so it does vascular smooth muscle contraction…often given in codes to raise bp

Question 15

Receptrs that fall into the Gq class

Answer 15

Qc’s HAVE 1 M&M

Means Gq receptors are H1, A1, V1, and M1 and M3

Question 16

Gs receptors do what

Answer 16

stimulate adenylyl cyclase

Question 17

Gi receptors inhibit,,,,what are the Gi receptors

Answer 17

MAD 2’s….M2, A2, D2

Question 18

Gq pathway— this is how the receptors mentioned above that fall into this category elicit the effect we just described

Answer 18

Activation of Gq receptor leads to activation of phospholipase C.

• This converts lipids to PIP2 which can then turn into DAG and IP3
• DAG turns into Protein Kinase C
• IP3 leads to increased calcium and smooth muscle contraction

Question 19

Gs pathway — this is how the receptors mentioned above that fall into this category elicit the effect we just described

Answer 19

Gs activation activates adenylyl cyclase
- Adenylyl cyclase activates ATP which stimulates cAMP to activate Protein Kinase A….leads to increased calcium in the heart and Myosin

Question 20

Gi inhibits the adenylyl cyclase pathway

Answer 20

ok