Anti-coagulation

Question 1

Aspirin mech.

Answer 1

Irreversibly inhibits COX-1 and COX-2 enzymes within the platelet. Platelets can’t make more so the platelets affected can’t make thromboxane A2 until they die and new platelets are produced (every 8-10 days).

Question 2

Labs when taking aspirin?

Answer 2

BT goes up

NO effect on PT or PTT.

Question 3

Toxicity of aspirin

Answer 3

• Gastric ulceration, tinnitus, chronic use can lead to acute renal failure.
• Reyes syndrome: Hepatoencephalopathy
• Overdose leads to respiratory alkalosis and metabolic acidiosis

Question 4

What are the ADP receptor inhibitors

Answer 4

Clopidogrel, Ticlopidine, Prasurgel, Ticagrelor

Question 5

How do the ADP inhibitors work

Answer 5

Block ADP receptor which generally accepts ADP to induce GpIIb/IIIa expression and thus allows fibrinogen to bind which links platelets.

Platelets can’t aggregate.