CYP450 Inducers and Inhibitors (Drug Metabolism) Flashcards
1
Q
Inhibitors mnemonic
A
CRACK AMIGOS C-cimetidine R- Ritonavir A- Amiodarone C- Cipro K- Ketoconazole
A- Acute alcohol M- Macrolides I- Isoniazid G- Grapefruit Juice O- Omeprazole S- Sulfas
2
Q
Cytochrome P450 enzymes are involved in what phase of drug metabolism
A
Phase 1- This is the phase that oxidizes, reduces, and hydrolyzes drugs. Also the phase that elderly ppl lose first
3
Q
Inducers mnemonic
A
Kenytoin Rides Shotgun in Barbies Girl Car
Phenytoin, Rifampin, St. Johns wart, Barbturates, Griseofulvin. Carbamezapojne and Chronic alc use
4
Q
Phase One is simple
A
Oxidation, reduction, hydrolysis
Metabolites are usually slightly polar, water solubele, and still active
5
Q
Phase II
A
Acetylation, Glucuronidation, Sulfation
Drugs are inactive and EXTREMELY POLAR which traps them in the urine
6
Q
Older ppl lose phase one
A
ok
