Diuretics Flashcards
Which Diuretics works at the Proximal Convoluted Tubule and Manitol
Acetazolamide
Which Diuretics works at the Proximal Convoluted Tubule and Manitol
Acetazolamide
What kind of Diuretic is Acetazolamide
Carbonic Anhydrase Inhibitor….Inhibits the function of carbonic anhydrase in the lumen which is to convert HCO3 into CO2 and water (which can be reabsorbed. No carb anhydrase and no reabsorption of water.
WHat is acetazolamide used for most
To get rid of bicarbonate…remember, alt sickness you hyperventilate which means you go into resp alkalosis becaue you blow off too much Co2. you can treat this by shedding bicarb.
Mannitol mech
Osmotic Diuretic: High tubular fluid osmolarity thus producing high urine flow.
Which diuretics can treat glaucoma
Acetazolamide and Mannitol….Acetazolamide: chronic
Mannitol: acute
Furosemide, Butenamide, Torosemide
All Loop DIuretics, work in thick ascending loop of henle. sulfa drugs
How do loop diuretics work
inhibit the Na, K, 2Cl cotransporter in the thick ascending loop of henle. Abolish the hypertonicity of the medulla so that the urine can’t be concentrated
Use LOOPS when you want to dump a ton of fluid
What do Loops Lose
Calcium
What retains calcium
Thiazides
Loop toxicity,,,besides the calcium
OH DANG! a loop!
O- ototoxic H- Hypokalemic D- dehydration A- allergy to sulfas N- Nephritis G- Gout
Thiazide diuretics
Inhibit NaCl reabsorption in distal convoluted tubule
Toxicity: Hyper GLUC
Hyper glycemia, Lipidemia, uricemia (gout), calcemia
Good for ppl that hve osteoporosis and HTN
BIG TIME HTN drug as opposed to loops
K sparing diuretics
Spironolactone, Triamterene, Amiloride
The K STAys
K spareres work where
collecting tubules
