Anti-arrhythmics Flashcards
4 classes of antiarrhythmics
No Bad boy Keeps Clean
Na channel blockers
Beta blockers
K- potassium channel blockers
C- calcium channel blockers
3 subclasses of Na channel blockers
1- Double quarter pounder
Disopyramide, procainamide, quinidine
2- Mayo Lettuce Tomato
Mexiletene Lidocaine Tocainemide
3- Fries Please
Flecanide propanefone
Mech of Beta Blockers
Decrease Cyclic AMP and Decrease Calcium
FLatten out Phase 4 of the Pacemaker AP
How do K channel blockers work?
Decrease the slope of phase 3 myocyte AP graph and inc Refractory period
2 most common potassium channel blockers
Sotalol and AMiodarone
Amiodarone can cause
Pulm fibrosis, hepatotoxicity, thyroid problems
Non-dihydropyridine calcium channel blockers work where?
Heart
Non dihydro calcium channel blockers
Verapamil and Diltiazem
How does adenosoine work
TOns of K out of cells thus hyperpolarizing the cell. Very short acting. Only lasts about 15 seconds