Anti-emetics

Question 1

Scopolamine mechanism

Answer 1

Muscarinic antagonist

Used for motion sickness, drug of choice.
Think of dad on the boat in keys. Needed scopolamine

Question 2

Promethazine

Answer 2

This is phenergran….it is a neuroleptic and has strong sedative effects but does prevent emesis. Just don’t give it to someone who needs to stay awake

Question 3

Metoclopramide

Answer 3

D2 receptor antagonist (remember the D2 receptor modulates neurotransmitter receptor release in the brain). Increases Resting tone of the LES. Doesn’t restrict colonic flow

Used as an antiemetic

Toxicity: increased parkinsonian effects. Restlessness, drowsiness, fatigue, depression, nausea, diarrhea

Question 4

Ondansetron

Answer 4

Serotonin receptor antagonist….powerful central acting antiemetic

Used to control vomiting in post-op pts and in chemo pts

Toxicity: headache and constipation