Receptor type Major Functions Flashcards
alpha1
Increase: vascular smooth muscle contraction, pupillary dilator muscle contraction (mydriasis), intestinal and bladder sphincter muscle contraction
alpha2
Decrease: sympathetic outflow, insulin release, lipolysis,
Increase: platelet aggregation
beta1
Increase: heart rate, contractility, renin release, lipolysis
beta2
Increase: vasodilation, bronchodilation, HR, contractility, lipolysis, insulin release, aqueous humor production, ciliary muscle relaxation
Decrease: Uterine tone (tocolysis)
M1
CNS, enteric nervous sytem
M2
Decrease: HR and atria contractility
M3
Increase: exocrine gland secretions (lacrimal, salivary, gastric acid), gut peristalsis, bladder contraction, bronchoconstriction, pupillary sphincter contraction (miosi), ciliary muscle contraction (accommodation)
D1
Relaxes renal vascular smooth muscle
D2
Modulates transmitter release, especially in brain
H1
Increase: Nasal and bronchial mucus production, vascular permeability, contraction of bronchioles, pruritus, and pain
H2
Increase: gastric acid secretion
V1
Increase vascular smoohtt muscle contraction
V2
Increase H2O permeability and reabsorption in the collecting tubules of the kidney