G-protein-linked 2nd messengers Classes Flashcards
1
Q
alpha1
A
q
2
Q
alpha2
A
i
3
Q
beta1
A
s
4
Q
beta2
A
s
5
Q
m1
A
q
6
Q
m2
A
i
7
Q
m3
A
q
8
Q
D1
A
s
9
Q
D2
A
i
10
Q
H1
A
q
11
Q
H2
A
s
12
Q
V1
A
q
13
Q
V2
A
s
14
Q
Which receptors are Gq
A
H1, alpha1, V1, M1, M3
15
Q
Which receptors are Gs
A
Beta1, beta2, D1, H2, V2
16
Q
Which receptors are Gi
A
M2, alpha2, D2
17
Q
What does Gq work on
A
Phospholipase C which turns PIP2 to DAG and IP3
18
Q
DAG and IP3 functions
A
DAG activates Protein Kinase C
IP3 increases ICF Ca2+ leading to muscle contraction
19
Q
What does Gs and Gi do
A
Work on adenylyl cyclase to modulate protein Kinase A to increase Ca2+ in heart and Myosin light-chain kinase (smooth muscle)
