G-protein-linked 2nd messengers Classes

Question 1

alpha1

Answer 1

q

Question 2

alpha2

Answer 2

i

Question 3

beta1

Answer 3

s

Question 4

beta2

Answer 4

s

Question 5

m1

Answer 5

q

Question 6

m2

Answer 6

i

Question 7

m3

Answer 7

q

Question 8

D1

Answer 8

s

Question 9

D2

Answer 9

i

Question 10

H1

Answer 10

q

Question 11

H2

Answer 11

s

Question 12

V1

Answer 12

q

Question 13

V2

Answer 13

s

Question 14

Which receptors are Gq

Answer 14

H1, alpha1, V1, M1, M3

Question 15

Which receptors are Gs

Answer 15

Beta1, beta2, D1, H2, V2

Question 16

Which receptors are Gi

Answer 16

M2, alpha2, D2

Question 17

What does Gq work on

Answer 17

Phospholipase C which turns PIP2 to DAG and IP3

Question 18

DAG and IP3 functions

Answer 18

DAG activates Protein Kinase C

IP3 increases ICF Ca2+ leading to muscle contraction

Question 19

What does Gs and Gi do

Answer 19

Work on adenylyl cyclase to modulate protein Kinase A to increase Ca2+ in heart and Myosin light-chain kinase (smooth muscle)