Drug Reactions

Question 1

Coronary vasospasm

Answer 1

cocaine, sumatriptan, ergot alkaloids

Question 2

Cutaneous flushing

Answer 2

Vancomycin, Adenosine, Niacin, CCBs [VANC]

Question 3

Dilated cardiomyopathy

Answer 3

Doxorubicin, daunorubicin

Question 4

Torsades de pointes

Answer 4

Class III and class IA antiarrhythmics, macrolide antibiotics, antipsychotics, TCAs

Question 5

Adrenocortical insufficiency

Answer 5

HPA suppression secondary to steroid withdrawal

Question 6

hot flashes

Answer 6

tamoxifen, clomiphene

Question 7

hyperglycemia

Answer 7

tacrolimus, protease inhibitors, niacin, HCTZ, beta-blockers, corticosteroids [taking pills necessitates having blood check]

Question 8

hypothyroidism

Answer 8

lithium, amiodarone, sulfonamides

Question 9

acute cholestatic hepatitis, jaundice

Answer 9

erythromycin

Question 10

diarrhea

Answer 10

metformin, erythromycin, colchicine, orlistat, acarbose [might excite colon on accident]

Question 11

focal to massive hepatic necrosis

Answer 11

halothane, amanita phalloides (death cap), valproate, acetaminophen [Liver HAVAc

Question 12

Hepatitis

Answer 12

INH

Question 13

Pancreatitis

Answer 13

Didanosine, corticosteroids, alcohol, valproate, azathioprine, diuretics [drugs causing a violent abdominal distress]

Question 14

pseudomembrnaous colitis

Answer 14

clindamycin, ampicillin, cephalosporins

Question 15

agranulocytosis

Answer 15

dapsone, clozapine, carbamaepine, colchicine, methimazole, propylthiouracil [drugs CCCrush myeloblasts and promyelocytes]

Question 16

aplastic anemia

Answer 16

carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, propylthiouracil [can’t make new blood cells properly]

Question 17

direct coombs-positive hemolytic anemia

Answer 17

methyldopa, penicillin

Question 18

gray baby syndrome

Answer 18

chloramphenicol

Question 19

hemolysis in G6PD deficiency

Answer 19

INH, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin [hemolysis IS D PAIN]

Question 20

megaloblastic anemia

Answer 20

Phenytoin, Methotrexate, Sulfa drugs

Question 21

Thrombocytopenia

Answer 21

Heparin, cimetidine

Question 22

Thrombotic complications

Answer 22

OCPs

Question 23

Fat redistribution

Answer 23

Protease inhibitors, glucocorticoids [Fat PiG]

Question 24

gingival hyperplasia

Answer 24

phenytoin, verapamil, cyclosporine, nifedipine

Question 25

hyperuricemia

Answer 25

pyrazinamide, thiazides, furosemide, niacin, cyclosporine (painful tophi and feet need care)

Question 26

myopathy

Answer 26

fibrates, niacin, colchicine, hydroxychloroquine, interferon-alpha, penicillamine, statins, glucocorticoids

Question 27

osteoporosis

Answer 27

corticosteroids, heparin

Question 28

photosensitivity

Answer 28

sulfonamides, amiodarone, tetracycliens, 5-FU

Question 29

Stevens-Johnsons

Answer 29

Anti-epileptics, allopurinol, sulfa drugs, penicillin

Question 30

SLE-like syndrome

Answer 30

Sulfa drugs, Hydralazine, INH, procainamide, phenytoin, etanercept [having lupus is SHIPP-E]

Question 31

Teeth discoloration

Answer 31

Tetracyclines

Question 32

Tendonitis, tendon rupture, and cartilage damage

Answer 32

Fluoroquinolones

Question 33

Cinchonism

Answer 33

quinidine, quinine

Question 34

parkinson-like syndrome

Answer 34

antipsychotics, reserpine, metoclopramide

Question 35

seizures

Answer 35

INH (B6 deficiency), bupropion, imipenem/cilastatin, tramadol, enflurane, metoclopramide

Question 36

tardive dyskinesia

Answer 36

antipsychotics, metoclopramide

Question 37

diabets insipidus

Answer 37

lithium, demeclocycline

Question 38

fanconi syndrome

Answer 38

expired tetracycline

Question 39

hemorrhagic cystitis

Answer 39

cylophosphamide, ifosfamide (prevent with coadministering mesna)

Question 40

interstitial nephritis

Answer 40

methicillin, NSAIDs, furosemide

Question 41

SIADH

Answer 41

carbamazepine, cyclophosphamide, SSRIs [can't concentrate serum sodium]

Question 42

dry cough

Answer 42

ACEIs

Question 43

Pulm. fibrosis

Answer 43

bleomycin, amiodarone, busulfan, methotrexate [breathing air badly from medications]

Question 44

disulfiram-like reaction

Answer 44

flagyl, certain cephalosporins, griseofulvin, procarbazine, 1st gen sulfonylurea

Question 45

nephrotoxicity/ototoxicity

Answer 45

aminoglycosides, vancomycin, loop diuretics, cisplatin

Question 46

antimuscarinic

Answer 46

atropine, TCAs, h1-blockers, antipsychotics

Question 47

sulfa drugs

Answer 47

probenecid, furosemide, acetazolamide, celecoxib, thiazides, sulfonamide antibiotics, sulfasalazine, sulfonylureas [Popular FACTSSS]