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Step 1 Pharmacology > Antineoplastics Clinical Uses > Flashcards

Antineoplastics Clinical Uses Flashcards

1
Q

MTX

A

Cancers: Leukemia, lymphomas, choriocarcinoma, sarcomas

Non-neoplastic: abortion, ectopic pregnancy, RA, psoriasis, IBD

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2
Q

5-FU

A

Colon cancer, pancreatic cancer, basal cell carcinoma (topical)

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3
Q

Cytarabine

A

Leukemias, lymphomas

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4
Q

6-MP, etc.

A

Preventing organ rejection, RA, SLE (azathioprine)

Leukemia, IBD (6-MP, 6-TG)

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5
Q

Dactinomycin

A

Wilms tumor, Ewing sarcoma, rhabdomyosarcoma, Used for childhood tumors (Children ACT out)

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6
Q

Doxorubicin (adriamycin)

A

solid tumors, leukemias, lymphomas

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7
Q

Bleomycin

A

Testicular cancer, Hodgkin lymphoma

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8
Q

Cyclophosphamide

A

Solid tumors, leukemia, lymphomas, and some brains cancers

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9
Q

Nitrosoureas

A

Brain tumors (GBM)

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10
Q

Busulfan

A

CML. Also used to ablate patient’s bone marrow before bone marrow transplantation.

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11
Q

Vincristine, vinblastine

A

Solid tumors, leukemias, lymphomas.

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12
Q

Packlitaxel, other taxols

A

Ovarian and breast carcinomas

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13
Q

Cisplatin, carboplatin

A

Testicular, bladder, ovary, and lung carcinomas

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14
Q

Etoposide, teniposide

A

Solid tumors (testicular and small cell lung), leukemias, lymphomas

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15
Q

Irinotecan, topotecan

A

Colon cancer (irinotecan); ovarian and small cell lung cancers (topotecan)

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16
Q

Hydroxyurea

A

melanoma, CML, sickle cell diseases (inc. HbF)

17
Q

Prednisone

A

CLL, non-HOdgkin lymphomas (part of combo chemo therapy). Immunosuppressants (AI diseases)

18
Q

Tamoxifen

A

Breast cancer tx (tamoxifen only) and prevention. Raloxifene is useful to prevent osteoporosis.

19
Q

Trastuzumab (Herceptin)

A

HER-2 + breast CA and gastric CA (tras2zumab)

20
Q

Imatinib (Gleevec)

A

CML, GI stromal tumors

21
Q

Rituximab

A

Non-Hodgkin lymphoma, RA (with MTX), ITP

22
Q

Vemurafenib

A

Metastatic melanoma

23
Q

Bevacizumab

A

Solid tumors (colorectal, renal cell carcinoma)

Step 1 Pharmacology (17 decks)

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