Parasympathetic Drugs

Question 1

Hemicholinium

Answer 1

blocks choline reuptake

Question 2

Vesamicol

Answer 2

Blocks ACh entrance into vesicles

Question 3

Botulinum

Answer 3

Prevents NT vesicle exocytosis

Question 4

Metyrosine

Answer 4

Blocks tyrosine to DOPA

Question 5

Reserpine

Answer 5

Blocks DA entrance into vesicles

Question 6

Bretylium, guanethidine

Answer 6

Blocks release of NE from vesicles?

Question 7

What does AT II receptors do

Answer 7

On presynaptic cell, increase release of NE

Question 8

Bethanechol

Answer 8

Cholinergic for bowel and bladder smooth muscle. Resistance to ACh

Question 9

Carbachol

Answer 9

ACh carbon copy. Glaucoma.

Question 10

Pilocarpine

Answer 10

Stimulates sweat, tears, and saliva. Open and closed angle glaucoma, resistant to ACh

Question 11

Methacholine

Answer 11

Muscarinic on airways when inhaled

Question 12

Neostigmine

Answer 12

AChEI: postop/neurogenic ileus

Question 13

Pyridostigmine

Answer 13

AChEI: Myasthenia gravis, no CNS penetration

Question 14

Physostigmine

Answer 14

Phyxes atropine overdose (crosses BBB)

Question 15

Donepezil, rivastigmine, galantamine

Answer 15

AChEIs for Alzheimers

Question 16

Edrophonium

Answer 16

Used for diagnosis of Myasthenia gravis, now use Anti-AChR Ab

Question 17

What conditions worsen with cholinomimetic agents?

Answer 17

COPD, asthma, peptic ulcers

Question 18

Cholinesterase inhibitor poisoning mnemonic

Answer 18

DUMBBELSS
Diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal muscle and CNS, Lacrimation, Sweating, and Salivation

Question 19

Antidote for Cholinesterase poisoning

Answer 19

Atropine (comp. inhib. + pralidoxime (regerenates AChE if given early)

Question 20

Atropine, homatropine, tropicamide

Answer 20

Muscarinic antagonists, mydriasis and cycloplegia

Question 21

Benztropine use

Answer 21

Antimuscarinic Parkinsons

Question 22

Scopolamine use

Answer 22

Antimuscarinic, Motion sickness

Question 23

Ipratropium, tiotropium use

Answer 23

Antimuscarinic, COPD and asthma

Question 24

Oxybutynin, darifenacin, and solifenacin

Answer 24

Antimuscarinic, reduce urgency in bladder

Question 25

Glycopyrrolate use

Answer 25

antimuscarinic: reduces airway secretions, drooling, peptic ulcer

Question 26

Atropine effects

Answer 26

Increases pupil dilation, cycloplegia | Decreases: secretions, acid secretion, motility, urgency in cystitis

Question 27

Atropine toxicity mnemonic

Answer 27

Hot as a hare, dry as bone, red as a beet, blind as a bat, mad as a hatter