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Step 1 Pharmacology > Parasympathetic Drugs > Flashcards

Parasympathetic Drugs Flashcards

1
Q

Hemicholinium

A

blocks choline reuptake

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2
Q

Vesamicol

A

Blocks ACh entrance into vesicles

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3
Q

Botulinum

A

Prevents NT vesicle exocytosis

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4
Q

Metyrosine

A

Blocks tyrosine to DOPA

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5
Q

Reserpine

A

Blocks DA entrance into vesicles

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6
Q

Bretylium, guanethidine

A

Blocks release of NE from vesicles?

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7
Q

What does AT II receptors do

A

On presynaptic cell, increase release of NE

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8
Q

Bethanechol

A

Cholinergic for bowel and bladder smooth muscle. Resistance to ACh

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9
Q

Carbachol

A

ACh carbon copy. Glaucoma.

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10
Q

Pilocarpine

A

Stimulates sweat, tears, and saliva. Open and closed angle glaucoma, resistant to ACh

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11
Q

Methacholine

A

Muscarinic on airways when inhaled

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12
Q

Neostigmine

A

AChEI: postop/neurogenic ileus

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13
Q

Pyridostigmine

A

AChEI: Myasthenia gravis, no CNS penetration

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14
Q

Physostigmine

A

Phyxes atropine overdose (crosses BBB)

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15
Q

Donepezil, rivastigmine, galantamine

A

AChEIs for Alzheimers

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16
Q

Edrophonium

A

Used for diagnosis of Myasthenia gravis, now use Anti-AChR Ab

17
Q

What conditions worsen with cholinomimetic agents?

A

COPD, asthma, peptic ulcers

18
Q

Cholinesterase inhibitor poisoning mnemonic

A

DUMBBELSS
Diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal muscle and CNS, Lacrimation, Sweating, and Salivation

19
Q

Antidote for Cholinesterase poisoning

A

Atropine (comp. inhib. + pralidoxime (regerenates AChE if given early)

20
Q

Atropine, homatropine, tropicamide

A

Muscarinic antagonists, mydriasis and cycloplegia

21
Q

Benztropine use

A

Antimuscarinic Parkinsons

22
Q

Scopolamine use

A

Antimuscarinic, Motion sickness

23
Q

Ipratropium, tiotropium use

A

Antimuscarinic, COPD and asthma

24
Q

Oxybutynin, darifenacin, and solifenacin

A

Antimuscarinic, reduce urgency in bladder

25
Q

Glycopyrrolate use

A

antimuscarinic: reduces airway secretions, drooling, peptic ulcer

26
Q

Atropine effects

A

Increases pupil dilation, cycloplegia

Decreases: secretions, acid secretion, motility, urgency in cystitis

27
Q

Atropine toxicity mnemonic

A

Hot as a hare, dry as bone, red as a beet, blind as a bat, mad as a hatter

Step 1 Pharmacology (17 decks)

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