receptor pharmacology Flashcards
what is the law of mass action
the more drug you add the more response you get
what underpins the ability of the drug to be attracted to the receptor
affinity
what does an agonist cause
a change in the receptor to give a response (efficacy)
what does potency mean
a measure of the concept of affinity
is there multiple receptors for the same endogenous agonist
yes
what receptors does histamine have
H1 and H2
what adrenoceptors are there
A1 and A2
B1, B2 and B3
what muscarinic receptors are there
M1-5
do receptors of the same family have any differences
yes they have structural differences in the site where the agonist binds
what does alpha adrenoceptors control
- vasoconstriction
- dilation of pupil
- contraction of uterus and ureters
- relaxation of intestinal movements
effects of beta adrenoceptors
- vasodilation
- stimulation of heart
- relaxation of uterus
is efficacy linked to potency
no
what is efficacy based on
the ability of the agonist to produce a conformational change in the receptor
what is a full agonist
an agonist with good efficacy
what is a partial agonist
an agonist that doesn’t reach the same levels as a full agonist
