Randop

Question 1

aptt

Answer 1

lab test used to evaluate the clotting ability of blood by measuring the time it takes for a clot to form in a plasma sample after adding an activator, phospholipid, and calcium

Question 2

isolated prolonged aptt

Answer 2

(aPTT) means that the aPTT is longer than normal, but other coagulation tests (such as prothrombin time [PT] and platelet count) are within the normal range.

Question 3

prothrombin time

Answer 3

how long it takes for blood to clot

Question 4

joint symptoms and hyper pigmented appearance

Answer 4

iron overload

Question 5

risk of regular transfusions

Answer 5

iron overload

Question 6

hbh disease

Answer 6

1/4 functioning alpha genes

Question 7

frontal bossing sign of

Answer 7

beta thalaessemia major

Question 8

vwf assoc

Answer 8

bleeding time prolonged
factor viii decreased
aptt increased ]

Question 9

joint bleeding

Answer 9

haemophilia

Question 10

nose bleeds, gum bleeding etc

Answer 10

vwd

Question 11

MOA of doacs

Answer 11

inhibtio of factor xa

Question 12

MOA of warfarin

Answer 12

vit k antagonist

Question 13

blood film finding on DIC

Answer 13

schisocytes

Question 13

what factor def is haemophilia b

Answer 13

factor IX

Question 14

what factor def do patients with haemo[hilia a have

Answer 14

factor viii

Question 15

foetal complication alpha thalassaemia

Answer 15

barts hydrops fetalis

Question 16

treatment of dvt for active cancer

Answer 16

doac for at least 3 months

Question 17

pt and aptt in ttp

Answer 17

normal

Question 18

pt and aptt in dic

Answer 18

prolonge d

Question 19

what does giving lmwh increase risk of immediately post op

Answer 19

bleeding

Question 20

what causes an elevated A2 level

Answer 20

beta thalaessmia trait

Question 21

who does non hodgkins usually present in

Answer 21

older people

Question 22

who does hodgkins usually present in

Answer 22

younger

Question 23

pentad of symptoms of thrombotic thrombocytopenic purpura

Answer 23

acute kidney injury, fever, low platelets, neurological features , microangiopathic anaemia

Question 24

what organisms are those with sickle cell disease susceptible to

Answer 24

strep penumo, haemophilus influenza, pseudomonas aurginosa

Question 25

myeloid lineage

Answer 25

innate response platelets rbcs granulocytes macrophages monocytes dendritic

Question 26

lymphoid lineage

Answer 26

adaptive response b cellls t cells nk cells

Question 27

What technique reliably identifies the cell-type (lineage)?

Answer 27

immunophenotyping

Question 28

what suppresses erythopoieses in polycythaemia vera

Answer 28

hydroxycarbamide

Question 29

essential thrombosis age relation

Answer 29

women in their 50-70s

Question 30

where do drugs inhibitng dna synthesis target

Answer 30

s phase

Question 31

leukoeryythroblastic

Answer 31

immature wbcs and rbcs in peripheral blood

Question 32

polycythaemia treatment

Answer 32

aspirin 75mg and venesection <45%

Question 33

treatment for essential thrombocythaemia if cant have aspirin aka if have asthma etc

Answer 33

hydroxyurea

Question 34

what might anabolic steroid use cause

Answer 34

secondry polycythaemia

Question 35

aplastic crisis

Answer 35

low retic count and severe anaemia due to paravirus b19

Question 36

low platelet count, prolonged bleeding time and mucosal bleeding

Answer 36

immune thrombocytopenic purpura

Question 37

first line treatment for immune thrombocytopenic purpura

Answer 37

steroids to suppress immune system to stop attacking platelets

Question 38

risk with heparin

Answer 38

heparin induced thrombocytopenia

Question 39

how to confirm hereditary spheroytosis

Answer 39

Eosin-5′-maleimide (EMA) binding test

Question 40

what might methotrexate cause

Answer 40

folate deficiency so must be co prescirbed

Question 41

first line treatment for chronic myeloid leukaemia

Answer 41

Imatinib

Question 42

fatigue, pallor, dizzy, tingling

Answer 42

b12 def

Question 43

g6pd inheritance

Answer 43

x linked recessive

Question 44

drug which suppresses erythrpoietin

Answer 44

hydroxycarbamide

Question 45

cause of aplastic crisis

Answer 45

parvovrius b19

Question 46

first line dvt

Answer 46

rivaroxaba - any doac