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Random .2 Flashcards

1
Q

MOA of rituximab

A

antibody whcih targets and kills cd20 positive b cells so works in b cell lymphomas

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2
Q

which anaemia causes koilonychia

A

iron def

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3
Q

worse afer hot bath

A

polycythaemia vera

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4
Q

first line investiugaton in GCA

A

plasma viscosity or esr

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5
Q

what is VWF a carrier for

A

factor 8

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6
Q

characteristics of myeloma

A

CRABBI
calcium rasied
renal imapirment
Anaemia,
Bones
Bleeding (thrombocytopaenia), and Infections (neutropaenia).

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7
Q

blood results of myeloma

A

hypercalcqemia
normal/ raised phosphate
normal alp

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8
Q

what can increase life span of red blood cells and so increasing hba1c

A

splenecomty

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9
Q

what does pernicous anaemia predispose to

A

gastric cancr

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10
Q

starry sky appearance

A

burkitts

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11
Q

multiple myeloma characteristics

A

roleoux formation, hypercalcaemia, anaemia, back pain- CRABBI pneumonic

confirmed with electrophoresis

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12
Q

first line management for warm autoimmune haemolytic anaemia

A

steroids and rituximab

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13
Q

first line chronic myeloid leukaemia

A

imatinib

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14
Q

do all myelomas show on electrophoresis

A

no

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15
Q

how is vaso occlusive crisis confirmed

A

doesnt need confirmation
confirmed via pain clinically

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16
Q

gold standard for non hodgkins

A

pet/ ct

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17
Q

heinz bodies

A

g6pd def

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18
Q

prophylactic drug for sickle cell

A

hydroxyurea

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19
Q

howell jolly bodies

A

coelic , hyposlenism

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20
Q

rivaroxaban moa

A

direct factor Xa inhibitor

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21
Q

taco v trali

A

trail is hypo taco is hyper

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22
Q

hand foot syndrome

A

swelling of hands and feet of child with sickle cell

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23
Q

what is taco treated with

A

loop diuretics

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24
Q

how is richters tranformation diagnosed

A

lymph node biopsy

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25
Q

first line treatment for ITP

A

oral prednisolone

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26
Q

what is autoimune haemolytic anaemia characterised by

A

coombs test

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27
Q

what transfusions are at risk of bacterial infection and why

A

platelets as they are stored at room temp

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28
Q

what is used for reversal of doac in patients with severe bleed/ head injury

A

prothrombin complex concentrate

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29
Q

what can cause an isolated rise in hb

A

polycythaemia vera

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30
Q

what is HIV a risk for in tersm of cancer

A

non hodgkins

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31
Q

isolated rise in ggt in macrocytic anaemia

A

alcoholism

32
Q

Exchange transfusion role

A

reduce number of sickle cells and increase numbe rof normal cells to improve oxygenation

33
Q

what might methptrexate therapy result in

A

megaloblastic macrocytic anaemia

34
Q

bite and bloster cells

35
Q

what type of cancer might polycythaemia rubra vera transform to

A

acute myeloid leukaemia

36
Q

investiagtion for non hodgkins

A

excisional node biopsy

37
Q

blue lines on gum margin

A

lead poisoning

38
Q

What type of anaemia does sickle cell cause

A

normocytic
rlow haemoglobin, normal nbc, raised retic

39
Q

raised hba2 in terms of thalassaemias

A

beta trait

40
Q

does alpha trait cause a raised hba2

41
Q

what type of drugs have adverse effect on g6pd patients

A

sulfa containing drugs

42
Q

what does a high tibc suggest

A

low iron in blood as there are more spots to fill up

43
Q

aplastic crisis

A

sudden drop in hb

44
Q

what should sickle cell patients be commeneced on to prevent crisis

A

hydroxycarbamide

45
Q

what can rivaroxaban and apixaban be revrsed by

A

andexanet alfa

46
Q

is fibrinogen high or low in dic

47
Q

what counteracts warfarin

48
Q

first line in polycythaemia vera

A

venesection- phlebotomy

49
Q

blood film of folate def

A

hyper segmented neutrophisl

50
Q

risk factor for non hodgkins

51
Q

does trali present with abdo pain

52
Q

acute haemolytic reaction symptoms

A

tachycardia, abdominal pain, fever, hypotension

53
Q

what is creatinine

A

waste product of ormal muscle metabolism breakdown

54
Q

protein def in ttp

55
Q

massive splenomegaly

A

chronic myeloid leukaemia

56
Q

translocation in cml

57
Q

what might ileocacael result in

58
Q

beefy red tongue

A

b12 def and folate

59
Q

acquired haemolysis main note

A

prolonged aptt

60
Q

first line for warm autoimmune haemolytic anaemia

A

steroids +/- rituximab

61
Q

medication for patients with polycythaemia vera to reduce dvt

62
Q

treatment for aps during pregnancy

A

aspirin and lmwh

63
Q

what can polycythaemia rubra v lead to

A

aml or myelofibrosis

64
Q

most causative organsim in neutropenic sepsis

65
Q

definitive diagnosis for sickle cell

A

electrophoresis

66
Q

what is alteplase used in

A

emergency situations

67
Q

what does cryoprecipitate contain

A

VWF, factor viii, fibrinogen and factor xiii

68
Q

which cancer has potential to involve CNS, testis and other extra marrow sites

69
Q

sequestrian criss retics

70
Q

aplastic crisis retics

71
Q

diagnostic for cll

A

bone marrow biopsy ansd immunophenotyping

72
Q

what are cabot rings highly suggestive of

A

pernicous anaemia

73
Q

in kids how does itp usually present

A

post viral infection
self limitting

74
Q

slapped cheek appearance

A

parvovirus b19

Haematology (32 decks)

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