Malignancies Flashcards
more common in children
acute lymphoblastic leukaemia
has cns involvement
Acute lymphoblastic leukaemmia
what is ALL often associated with
Down syndrome
chromosome abnormality in chronic myeloid leukamia
philadelphia chromsome
what does chronci myeloid leukamia involve
translocation of long arms 9 and 22 resulting in BCR-AB21
What genetic testing will show philadelphia chromosome
FISH
What might inhibit platelet function
kinase inhibitors
what are smear cells
ruptured white blood cells appearing disrupted or broken
what are auer rods indicative of
acute myeloid leukaemia
what cancer may show smear cells
chronic lymphocytic leukaemia
which cancer usually presents in males over 60
chronic lymphocytic leukaemia
which presents with splenomegaly
chronci myeloid leuakami
what do those wtih AML laxk
platelets
what does acute lymphoblastic leukamia show
leukamic lymphoblastic cells
which cancer leads to richster transformstion
chronic lymphoblastic leukaemia
poor prognosis in hodgkins
elevated ear/ decreased hb
target cation of rituximab
cd20
translocation of what chromsomes in burkitts lymphom
8 adn 14
mantle cell lymphma translocations
11 and 14
acute lympholastic summary
cns involvement
bone pain
in children
chemo
rapid progression
acute myeloid summary
rapid progression
over 60s
not producing abcs, rbcs or platelets as maturation blocked
auer rods
may showpacytopenia
easy brusiing
translocatoin 15;17 favourable prognosis
chronic myeloid leukaemia summary
three phases - chronic, accelerated, blast
splenomegaly, hypermetabolic symptoms, gout
tyrosine kinase inhibitor
philadelphia chromosome abnormality
chronic lymphoblasdtic summary
smear cells
ver 55 males
autoimmune assoc only treat with steroids
if have weight lsos etc then treat
smudge cells
rubbery non. tender lymph node
hodgkins
hodgkins v non age
hodgkins in younger
non in older
starry sky appearance
epsteinn barr virus
8 and 14
burkitts
reed sternberg cell
hodgkins
irregular nucleus high mitotic rate on biopsy
non hodgkins
