Amyloidosis Flashcards
1
Q
amyloidosis
A
faulty proteins that instead of having the wrong shape they clump together to form insoluble aggregates in tissue
2
Q
name for the protein aggregates
A
amyloid
3
Q
what is AL amyloidosis due to
A
small plasma cell clone
4
Q
what does amyloid accumulation in tissues cause
A
organ damage
5
Q
organ damage examples in AL amyloid
A
Kidney
Nephrotic syndrome
Heart
Cardiomyopathy
Liver
Organomegaly, deranged LFT’s
Neuropathy
Autonomic
Peripheral
GI tract
Malabsorption
6
Q
amyloid diagnosis and staging
A
Organ biopsy confirming AL amyloid deposition
Congo red stain
Rectal or fat biopsy made be done if high clinical suspicion (less invasive)
Evidence of deposition in other organs
SAP scan
Echocardiogram/cardiac MRI
Nephrotic range proteinuria
7
Q
A
