Random Facts

Question 1

Sexually Transmitted diseases that must be reported to the CDC:

Answer 1

N. gonorrhea
C. trachomatis
Hep B (acute, chronic, and perinatal)
Hep C (acute, past or present)
HIV

Question 2

Bruton’s Agammaglobulinemia

Wiskott-Aldrich Syndrome

G6PD Deficiency

Lesch-Nyhan Syndrome

DMD

Hemophilia A and B

Answer 2

X-linked recessive diseases

Question 3

Rifampin Up may car before I get Phenytoined at St. John’s Phenobarabershop where they are nevirapine on time, always drinking ETOH and always eats the gristle off of their steaks. Dexter has narcolepsy but is Nafsty with the clippers”

Answer 3

CYP450 Inducers:

Rifampin
Carbamazepine
Phenytoin
St. John's Wort
Nevirapine
chronic ETOH
Griseofulvin
Modafinil
Phenobarbital
Dexamethasone
Nafcillin

Question 4

What type of HS reaction is TB reactivation?

Answer 4

Type IV:

T cells and macrophages initiate granulomatous inflammation

Question 5

SICKFACES.COM when I am drinking Grapefruit juice

Answer 5

CYP450 inhibitors:
sodium valproate
INH
Cimetidine
Ketoconazole
Fluconazole
Acute EtOH abuse
Chloramphenicol
Erythromycin/Clarithromycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole
Amiodarone
Grapefruit Juice

Question 6

Always Think When Outdoors:

Answer 6

CYP450 substrates:

Anti-eleptics
Theophylline
Warfarin
OCPs

Question 7

Anti-Jo Abs:

Answer 7

Polymyositis

Question 8

Cellular infiltrate within the muscle fascicle with inflammatory cells invading individual muscle fibers

Answer 8

Polymyositis

Question 9

Focal endomysial infiltration by CD8+ T lymphocytes and macrophages, capillary obliteration, endothelial cell damage, and increased amount of CT d/t muscle fiber necrosis

Answer 9

Histopathology for polymyositis

Question 10

insidious onset of symmetrical, proximal muscle weakness in UE and LE; muscle pain and tenderness

Answer 10

Polymyositis

Question 11

Elevated serum creatinine kinase, LDH, and aldolase.

Anti-Jo Abs

Answer 11

Polymyositis labs

Question 12

Pentad of TTP:

Answer 12

Microangiopathic hemolytic anemia, thrombocytopenic purpura, neurologic abnormalities, fever, renal disease

Question 13

Pathophys of TTP:

Answer 13

Deficiency in ADAMTS13 protease that cleaves vWF multimers into smaller vWF monomers leading to anemia from RBC trauma from vWF multimers and thrombocytopenia from platelets aggregating onto large multimers

Question 14

Malignant ovarian tumor of epithelial origin that secretes serous material:

Answer 14

Papillary serous adenocarcinomas

Question 15

Most common type of primary ovarian malignancy

Answer 15

Papillary serous cystadenocarcinoma

Question 16

Primary ovarian malignancy associated with intraperitoneal deposits:

Answer 16

Papillary serous cystadenocarcinoma

Question 17

Tx of neuroleptic malignant syndrome:

Answer 17

Dantrolene (1st line)–interferes with calcium release from the sarcoplasmic reticulum within muscle cells

Bromocriptine–dopamine agonist

Question 18

Monoclonal Ab treatment/prophylaxis of inhalational anthrax:

Answer 18

Raxibamucab–neutralizes the toxin formed by B. anthracis

Question 19

Carcinoid tumors don’t show symptoms until…

Answer 19

they metastasize to the liver

Question 20

Leutinized follicle cysts that form as a result of overstimulation of theca interna cells from high levels of bHCG

Answer 20

theca lutein cysts

Question 21

Most common sex cord stromal tumor:

Answer 21

ovarian fibroma

Question 22

Histo of ovarian fibromas:

Answer 22

spindle-shaped fibroblasts

Question 23

Meig’s syndrome:

Answer 23

Ovarian fibroma, ascites (fluid wave on abdominal palpation), pleural effusion

Question 24

a1 receptor signaling:

Answer 24

Gq protein –> increased intracellular calcium –> increased smooth muscle contraction, pupillary dilator muscle contraction, increased intestinal and bladder sphincter muscle contraction

Question 25

B1 receptor signaling:

Answer 25

Gs signaling protein increased contractility, increased HR, increased renin release and lipolysis

Question 26

B2 receptor signaling:

Answer 26

Gs signaling protein: vasodilation (by inhibition of MLCK), bronchodilation, increase HR & contractility, lipolysis, insulin release and decreased uterine tone

Question 27

a2 receptor signaling:

Answer 27

Gi receptor signaling: inhibits adenylyl cyclase--> decrease in smooth muscle contraction decreased sympathetic outflow, decreased insulin secretion, decreased lipolysis, increased platelet aggregation, decrease aqueous humor production

Question 28

Agar for Legionella pneumophila:

Answer 28

charcoal yeast agar enriched with cysteine and iron

Question 29

2 drugs recommended for systolic CHF and volume overload known to improve survival;

Answer 29

ACEIs and diuretics

Question 30

drugs recommended for prior CHF and decreased ejection fraction:

Answer 30

beta blocker

Question 31

Innervation to the palmar surface and nail beds of the 1st 3 digits

Answer 31

median nerve

Question 32

innervation of the thenar muscles and pronator teres:

Answer 32

median nerve

Question 33

innervation of the adductor pollicis

Answer 33

deep branch of the ulnar nerve

Question 34

atypical lymphocytosis, positive latex agglutination (Monospot test) and positive heterophile Ab

Answer 34

Infectious mononucleosis d/t EBV

Question 35

CAG trinucleotide repeat:

Answer 35

Huntington Dz, cx 4, AD

Question 36

CGG trinucleotide repeat:

Answer 36

Fragile X Syndrome, X cx, XLD

Question 37

CTG trinucleotide repeat:

Answer 37

Myotonic dystrophy, DMPK gene AD

Question 38

GAA trinucleotide repeat

Answer 38

Friederich ataxia, cx 9, AR

Question 39

Nuetrophilic infiltration of the thyroid gland:

Answer 39

DeQuervain's thyroiditis

Question 40

Alz. dementia with an associated Parkinson-like movement disorder + hallucinations

Answer 40

Lewy body dementia

Question 41

leukotriene excess d/t inhibition of COX causing bronchoconstriction and wheezing

Answer 41

ASA induced asthma

Question 42

MC cause of bacterial parotitis:

Answer 42

S. aureus

Question 43

Unilateral and common among older popn d/t medications with atropine effect of reduced salivary flow:

Answer 43

bacterial parotitis

Question 44

Most common cause of aseptic meningitis:

Answer 44

enterovirus

Question 45

Effects of insulin on K+ levels:

Answer 45

insulin shift K+ into cells

Question 46

Anticipation due to ______ instability in myotonic dystrophy:

Answer 46

maternal meiosis

Question 47

Anticipation due to _____ instability in Friederich's Ataxia:

Answer 47

maternal and paternal meiosis

Question 48

Anticipation due to _____ instability in Huntington's Dz:

Answer 48

paternal meiosis

Question 49

negatively regulates PI3k/AKT pathway

Answer 49

PTEN tumor suppressor gene. When both copies are lost, can lead to breast, prostate and endometrial cancer

Question 50

Cryptococcus neoformans colonizes what organ?

Answer 50

the lungs

Question 51

PCP is a...

Answer 51

NMDA receptor antagonist

Question 52

CKD phosphate and calcium levels:

Answer 52

low serum calcium high serum phosphorus high PTH

Question 53

Anesthetics with a high tissue solubility have a high...

Answer 53

arteriovenous concentration gradient and slower onset of action

Question 54

Prophylaxis before rabies exposure:

Answer 54

inactivated vaccine

Question 55

Post exposure rabies prophylaxis

Answer 55

inactivated vaccine and rabies immune globin

Question 56

symptom/finding essential for TTP dx:

Answer 56

hemolytic anemia

Question 57

the ophthalmic artery is a branch of...

Answer 57

the internal carotid artery

Question 58

opiate of choice in acute pancreatitis...

Answer 58

meperidine b/c it does not increase pressure at the sphincter of oddi

Question 59

deficiency of uroporphyrinogen decarboxylase

Answer 59

porphyria cutanea tarda

Question 60

deficiency of porphobilinogen deaminase

Answer 60

acute intermittent porphyria

Question 61

what is increased in the urine in acute intermittent porphyria

Answer 61

d-ALA and porphobilinogen

Question 62

red urine is seen in

Answer 62

acute intermittent porphyria--porphobilinogen deaminase deficiency

Question 63

major AEs of SSRIs:

Answer 63

sexual dysfunction and GI sx (nausea, diarrhea)

Question 64

where do goblet cells in the respiratory system stop?

Answer 64

just before the terminal bronchioles at the bronchi

Question 65

fever and mucocutaneous lesions that progress to epidermal necrosis and sloughing after use of certain medications:

Answer 65

Steven Johnson's syndrome

Question 66

Most commonly implicated drugs in SJS:

Answer 66

lamotrigine, allopurinol, sulfonamide antibiotics (TMP/SMX), anticonvulsants (carbamazepine, phenytoin)

Question 67

mutations in melanoma

Answer 67

BRAF