Immuno Cells and Cytokines

Question 1

CD3
TCR–binds Ag-MHC complex
CD28–binds B7 on APC

Answer 1

T cell markers

Question 2

CD3
TCR
CD28
CD4
CD40L
CXCR4/CCR5 (co-receptor for HIV)

Answer 2

Th cell markers

Question 3

CD3
CD8
TCR
CD28

Answer 3

Cytotoxic T cell markers:

Question 4

CD3
CD4
CD28 TCR
CD25

Answer 4

Reg Cell markers:

Question 5

Ig
CD 19, CD20, CD21 (receptor for EBV)
CD40
MHC II
B7:

Answer 5

B cell markers

Question 6

CD14
CD40
CCR5
MHC II, B7 (CD80/86)
Fc and C3b receptors (enhanced phagocytosis)

Answer 6

Macrophage cell markers

Question 7

CD16

CD56 (suggestive marker for NK cells)

Answer 7

NK cell markers

Question 8

Hematopoietic stem cell marker:

Answer 8

CD34

Question 9

CD117 and CD 25

Answer 9

mast cell markers

Question 10

induces T cell differentiation into Th1 cells and activates NK cells

Answer 10

IL-12

Question 11

activates endothelium, causes WBC recruitment, vascular leak

Answer 11

TNF-a

Question 12

causes cachexia in malignancy

Answer 12

TNF-a

Question 13

maintains granuloma in TB

Answer 13

TNF-a

Question 14

mediates fever and sepsis

Answer 14

IL-1, IL-6, TNF-a

Question 15

stimulates macrophages to kill phagocytosed pathogens

Answer 15

IFN-gamma

Question 16

inhibits differentiation of Th2 cells

Answer 16

IFN-gamma

Question 17

enhances class switching to IgA

Answer 17

IL-5

Question 18

enhances class switching to IgE and IgG

Answer 18

IL-4

Question 19

synthesized by infected viral cells that act on local cells, priming them for viral defenses by downregulating protein synthesis to resist potential viral replication and upregulating MHC expression to facilitate recognition of infected cells

Answer 19

interferons