Immunohistochemistry stains

Question 1

Proteins involved in cell adhesion:

Answer 1

cadherins

Question 2

N-cadherins are found in:

Answer 2

neurons

Question 3

Squamous cells or glandular epithelium stains for:

Answer 3

cytokeratin

Question 4

secretory protein found in vesicles of endocrine and neuro-endocrine cells:

Answer 4

chromogranin

Question 5

Part of cell adhesion apparatus AND involved in cell signaling:

Answer 5

B-catenin

Question 6

Intermediate filament found near the Z line of sarcomeres:

Answer 6

desmin

Question 7

desmin stains for:

Answer 7

muscle cell tumors

Question 8

vimentin stains for:

Answer 8

mesenchymal tumors

Question 9

S-100 stains for:

Answer 9

neural crest cells

Question 10

GFAP stains for:

Answer 10

neuroglia (astrocytes, schwann cells, oligodendrocytes)

Question 11

neurofilament stains for:

Answer 11

neurons

Question 12

PSA stains for:

Answer 12

prostatic epithelium in prostate CA

Question 13

TRAP stains for:

Answer 13

hairy cell leukemia

Question 14

Chromogranin stains for:

Answer 14

neuroendocrine cells

Question 15

ALP:

Answer 15

mets to bone or liver, Paget dz of bone, seminoma (placental ALP)

Question 16

AFP:

Answer 16

HCC, endodermal sinus tumor (yolk sac tumor), mixed germ cell tumor, ataxia telangiectasia, NTDs

Question 17

b-HCG

Answer 17

hydatidiform moles and choriocarcinoma, testicular CA, mixed germ cell tumor

Question 18

CA15-3/CA27-29

Answer 18

breast CA

Question 19

CA 19-9

Answer 19

pancreatic cancer

Question 20

CA 125

Answer 20

ovarian cancer

Question 21

calcitonin:

Answer 21

medullary thyroid carcinoma

Question 22

CEA

Answer 22

colorectal and pancreatic cancers

minor: gastric, breast, and medullary thyroid carcinomas

Question 23

chromogranin:

Answer 23

neuroendocrine tumors

Question 24

LDH

Answer 24

testicular germ cell tumors, ovarian dysgerminoma

Question 25

PSA:

Answer 25

prostate CA; can be elevated in BPH or prostatits