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Lung Cancers Flashcards

1
Q

Location of lung adenocarcinoma

A

peripheral

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2
Q

Epidemiology of lung adenocarcinoma:

A

MOST COMMON

Female (smokers) > Male (nonsmokers)

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3
Q

Cell origin of lung adenocarcinoma:

A

Clara cells

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4
Q

Stain positivity for lung adenocarcinoma:

A

mucin

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5
Q

Histo for lung adenocarcinoma:

A

glandular; thickening of alveolar walls, tall columnar cella

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6
Q

Mutations in lung adenocarcinoma:

A 
KRAS
RET
EGFR
ROS
ALK
MET
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7
Q

Location of squamous cell carcinoma:

A

central

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8
Q

RF for squamous cell carcinomas

A

smoking

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9
Q

CXR in squamous cell carcinoma

A

hilar mass from bronchus with cavitation

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10
Q

Histo for Squamous cell carcinoma:

A

keratin pearls with intracellular bridging

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11
Q

Paraneoplastic syndrome in Squamous cell carcinoma:

A

Hypercalcemia d/t secretion of PTHrP

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12
Q

Location of large cell lung carcinoma:

A

peripheral

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13
Q

Histo for large cell lung carcinoma:

A

highly anaplastic, undifferentiated cells

pleomorphic giant cells

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14
Q

RF for large cell lung carcinoma:

A

smoking

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15
Q

AE of large cell lung carcinoma:

A

gynecomastia; poor prognosis

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16
Q

Location for bronchial carcinoid:

A

central or peripheral

17
Q

Syndrome seen with bronchial carcinoid:

A

carcinoid syndrome: wheezing, flushing, diarrhea, R-sided heart lesions

18
Q

Histo for bronchial carcinoid:

A

nests of neuroendocrine cells

19
Q

Stain for bronchial carcinoid:

A

chromogranin A +

20
Q

Other locations for carcinoid tumors:

A

GI tract

MC TUMOR OF THE APPENDIX

21
Q

Location of small cell (oat cell) carcinoma:

A

central

22
Q

Histo for small cell carcinoma:

A

increase nucleus:cytoplasm ratio

neuroendocrine cells–small blue dark cells

23
Q

RF for small cell carcinoma:

A

smoking

24
Q

Stain for small cell carcinoma:

A

chromogranin A +
neuron-specific enolase +
synaptophysin +

25
Q

Paraneoplastic syndromes associated with small cell carcinoma:

A

Cushings–ACTH
SIADH–ADH
Abs to pre-synaptic calcium channels (Lambert Eaton syndrome)

26
Q

Mutations associated with small cell lung carcinoma:

A

tp53
Rb
myc mutations (amplification)

27
Q

Location of mesothelioma:

A

pleura

28
Q

RF for mesothelioma:

A

asbestos exposure, NOT SMOKING

29
Q

AE of mesothelioma:

A

hemorrhagic pleural effusion

30
Q

Stain in mesothelioma:

A

calretinin +

31
Q

What is seen on CXR in mesothelioma:

A

pleural thickening

32
Q

What is seen on histo in mesothelioma:

A

psamomma bodies

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