Lung Cancers Flashcards
Location of lung adenocarcinoma
peripheral
Epidemiology of lung adenocarcinoma:
MOST COMMON
Female (smokers) > Male (nonsmokers)
Cell origin of lung adenocarcinoma:
Clara cells
Stain positivity for lung adenocarcinoma:
mucin
Histo for lung adenocarcinoma:
glandular; thickening of alveolar walls, tall columnar cella
Mutations in lung adenocarcinoma:
KRAS RET EGFR ROS ALK MET
Location of squamous cell carcinoma:
central
RF for squamous cell carcinomas
smoking
CXR in squamous cell carcinoma
hilar mass from bronchus with cavitation
Histo for Squamous cell carcinoma:
keratin pearls with intracellular bridging
Paraneoplastic syndrome in Squamous cell carcinoma:
Hypercalcemia d/t secretion of PTHrP
Location of large cell lung carcinoma:
peripheral
Histo for large cell lung carcinoma:
highly anaplastic, undifferentiated cells
pleomorphic giant cells
RF for large cell lung carcinoma:
smoking
AE of large cell lung carcinoma:
gynecomastia; poor prognosis
Location for bronchial carcinoid:
central or peripheral
Syndrome seen with bronchial carcinoid:
carcinoid syndrome: wheezing, flushing, diarrhea, R-sided heart lesions
Histo for bronchial carcinoid:
nests of neuroendocrine cells
Stain for bronchial carcinoid:
chromogranin A +
Other locations for carcinoid tumors:
GI tract
MC TUMOR OF THE APPENDIX
Location of small cell (oat cell) carcinoma:
central
Histo for small cell carcinoma:
increase nucleus:cytoplasm ratio
neuroendocrine cells–small blue dark cells
RF for small cell carcinoma:
smoking
Stain for small cell carcinoma:
chromogranin A +
neuron-specific enolase +
synaptophysin +
