Ra223

Question 1

What is the half-life of Ra223?

Answer 1

11.4 days

Question 2

What is the energy of Ra223?

Answer 2

6.6 MeV

Question 3

Ra223 Xofigo

Answer 3

It is indicated for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.

Question 4

Ra223 Xofigo Clinical Pharmacology

Answer 4

It mimics calcium and forms complexes with the bone mineral hydroxyapatite at areas of increased bone turnover; such as bone metastases. The high linear energy transfer of alpha emitters leads to a high frequency of double strand DNA breaks in adjacent cells, resulting in an anti-tumor effect on bone metastases.

Question 5

Ra223 Xofigo Dose & Administration

Answer 5

1.35 mCi per kg body weight, given at 4-week intervals for 6 injection. Administer Xofigo slow IV over 1 minute.

Question 6

What does Ra223 indicated for?

Answer 6

It is a treatment for patients with castration-resistant prostate cancer.

Question 7

What does Ra223 mimic?

Answer 7

It mimics calcium and forms complexes with the bone mineral hydroxyapatite at areas of increased bone turnonver.