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Nuclear Medicine Radiopharmacy II > Fluorine 18 > Flashcards

Fluorine 18 Flashcards

1
Q

What is the half-life?

A

110 min

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2
Q

What are the energies?

A

634 keV and 2x511 keV

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3
Q

F18 Amyvid Florbetapir

A

PET tracer used to image the brain to estimate neuritic plaques.

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4
Q

F18 Amyvid Florbetapir Clinical Pharmacology

A

Florbetapir F18 diffuses across the blood brain barrier and produces a radioactivity signal detectable throughout the brain, and it binds to beta amyloid plaques. A negative scan shows no sign of neuritic plaques. A positive scan shows an increase of activity in the frontal lobe.

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5
Q

F18 Amyvid Dose & Administration

A

10 mCi through IV administration

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6
Q

F18 Cerianna Fluoroestradiol

A

PET agent used to detect estrogen receptors. Positive lesions in patients with recurrent or metastatic breast cancer.

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7
Q

F18 Cerianna Fluoroestradiol Clinical Pharmacology

A

Fluoroestradiol binds to estrogen receptors that show in positive breast cancer cells.

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8
Q

F18 Cerianna Fluoroestradiol Dose & Administration

A

6 mCi through IV over 1 -2 minutes.

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9
Q

F18 FDG

A

Oncology: observing abnormal glucose metabolism in patients with malignant tumors.
Cardiology: identifies the left ventricular myocardium with residual glucose metabolism and reversible loss of systolic function in patients with CAD.
Neurology: identifies regions of abnormal glucose metabolism

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10
Q

F18 FDG Clinical Pharmacology

A

concentrates in cells that need glucose. Glucose transporting proteins transport FDG through the cell membrane and is then phosphylated by hexokinase.

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11
Q

F18 FDG Dose and Administration

A

5-10 mCi through IV

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12
Q

F18 Fluciclovine Axumin

A

PET tracer used to image patients with suspected prostate cancer recurrence.

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13
Q

F18 Fluciclovine Axumin Clinical Pharmacology

A

Fluciclovine is a synthetic amino acid that gets transported across the mammalian cells by the amino acid transporters. These transporters uptake in prostate cancer cells, and F18 uptake is greater compared to normal tissue cells. A positive scan shows high PSA values.

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14
Q

F18 Fluciclovine Axumin Dose & Administration

A

10 mCi through IV.
Before administration, patient must be NPO for four hours and have not exercise for 24 hours.
A 20-30 min scan is taken after 5 min post-injection.

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15
Q

F18 NaF

A

PET imaging used for bone to find areas of abnormal ostengenic activity.

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16
Q

F18 NaF Clinical Pharmacolgy

A

Fluoride F18 ion accumulates in the skeleton in an even distribution fashion. There is greater despostion in the axial skeleton than the appendicular skeleton and greater despostion in the bones around the joints than the shafts of the long bones. An increased F18 ion occurs in bone areas of ostengenic areas during growth, infection, and inflammation of the bone.

17
Q

F18 NaF Dose & Administration

A

8-12 mCi through IV and 0.5 mCi for pediatrics.

After administration, drink plenty of water and image an hour after injection.

18
Q

F18 Neuraceq Florbetaben

A

PET imaging for the brain to estimate neural plaques in patients with Alzheimer’s Disease and other cognitive decline.

19
Q

F18 Neuraceq Florbetaben Clinical Pharmacolgoy

A

Florbetaben binds with beta amyloids plaques and produces a signal that can be detected by the PET scanner. However, neither Neuraceq and Florbetaban does not bind to tau and AT8 positive tau. Neuraceq crosses the blood brain barrier and shows differential regions that contain beta amyloid deposits. A positive scan shows higher uptake in grey matter than white matter.

20
Q

F18 Neuraceq Florbetaben Dose & Administration

A

8 mCi through IV

21
Q

F18 Tauvid Florataucipir

A

PET imaging for the brain to estimate density and distribution of neurofibrillary tangles in patients suspected of having Alzheimer’s Disease.

22
Q

F18 Tauvid Florataucipir Clinical Pharmacology

A

Florataucipir binds to tau proteins, which aggregates to form NFTs - an indication of Alzheimer’s Disease. In vitro, florataucipir binds to paired helical filaments from brain homogenates. In vivo, florataucipir binds differently in areas containing aggregated tau. A positive scan will show an increase activity in PLT, occipital, or parietal regions.

23
Q

F18 Tauvid Florataucipir Dose & Administration

A

10 mCi through IV

A 20 min scan is done after 80 min post-injection

24
Q

F18 Vizamyl Flutemetamol

A

PET imaging for the brain to estimate neuritic plaques

25
Q

F18 Vizamyl Flutemetamol Clinical Pharmacology

A

Flutemetamol binds to beta amyloid plaques and produces a positron signal. It binds to fibrillar beta amyloid in post mortem brain. A positive scan shows an increase activity in frontal, lateral, and parietal lobes.

26
Q

F18 Vizamyl Flutemetamol Dose & Administration

A

5 mCi though bolus IV within 40 seconds. Contraindications include hypersensitivity to vizamyl.
A 20 min scan is done after 90 min post injection.

27
Q

Name four radiopharmaceuticals focuses on brain imaging.

A

Amyvid Florbetapir
Neuraceq Florbetaben
Tauvid Florataucipir
Vizamyl Flutemetamol

28
Q

Name the radiopharmacetical that focuses on prostate cancer.

A

Fluciclovine Auxmin

29
Q

Name the radiopharmaceutical that focuses on breast cancer.

A

Cerianna Fluoroestradiol

30
Q

Name the radiopharmaceutical that focuses on bone.

A

NaF

31
Q

Name the radiopharmaceutical that focuses on glucose metabolism.

A

FDG

32
Q

Which PET tracer uses post mortem brain?

A

Vizamyl Flutemetamol

33
Q

Which PET tracer(s) does not require a post injection time for brain imaging?

A

Amyvid Florbetapir & Neuraceq Florbetaben

34
Q

Which PET tracer does a 20 min scan after 90 min post-injection?

A

Vizamyl Flutemetamol

35
Q

Which PET tracer does a 20 min scan after 80 min post-injection?

A

Tauvid Florataucipir

Nuclear Medicine Radiopharmacy II (18 decks)

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