I123

Question 1

What is the half-life of I123?

Answer 1

13.3 hours

Question 2

What is the energy of I123?

Answer 2

159 keV

Question 3

I123 Iobenguane (AdreView)

Answer 3

AdreView is indicated in the detection of primary or metastatic pheochromocytoma or neuroblastoma as an adjunct to other diagnostic test.

Question 4

I123 Iobenguane Clinical Pharmacology

Answer 4

Iobenguane is similar in structure to the antihypertensive drug guanethedine and to the neurotransmitter norepinephrine (NE). Iobenguane is, therefore, largely subject to the same uptake and accumulation pathways as NE. Iobenguane is taken up by the NE transporter in adrenergic nerve terminals and stored in the presynaptic storage vesicles. Iobenguane accumulates in adrenergically innervated tissues such as the adrenal medulla, salivary glands, heart, liver, spleen and lungs as well as tumors derived from the neural crest. Iobenguane is rapidly cleared from the blood and accumulates in adrenergically innervated tissues. Retention is especially prolonged in highly adrenergically innervated tissues

Question 5

I123 Dose & Administration

Answer 5

10 mCi through IV
Before administration, it is important that the patient has been administered with Potassium Iodide Oral Solution or Lugool’s Solution to block the uptake of I123 in the thyroid. Administer an hour before AdreView.

Question 6

I123 Ioflupane

Answer 6

a radiopharmaceutical indicated for striatal dopamine transporter visualization using SPECT brain imaging to assist in the evaluation of adult patients with suspected Parkinsonian syndromes (PS). In these patients, DaTscan may be used to help differentiate essential tremor from tremor due to PS (idiopathic Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy).

Question 7

I123 Ioflupane Clinical Pharmacology

Answer 7

In vitro, ioflupane binds reversibly to the human recombinant dopamine transporter. Autoradiography of post-mortem human brain slices exposed to radiolabeled ioflupane shows concentration of the radiolabel in striatum (caudate nucleus and putamen). The binding in the cortex and thalamus is mainly to the serotonin reuptake sites.

Question 8

I123 Ioflupane Dose & Administration

Answer 8

3-5 mCi through IV\
Before administration, it is important that the patient has been administered with Potassium Iodide Oral Solution or Lugool’s Solution to block the uptake of I123 in the thyroid. Administer an hour before.

Question 9

I123 NaI

Answer 9

Administration of Sodium Iodide I 123 is indicated as a

diagnostic procedure to be used in evaluating thyroid function and/or morphology

Question 10

I123 NaI Clinical Pharmacology

Answer 10

Sodium Iodide I 123 is readily absorbed from the upper gastrointestinal tract. Following absorption, the iodide is distributed primarily within the extracellular fluid of the body. It is trapped and organically bound by the thyroid and
concentrated by the stomach, choroid plexus and salivary glands. It is excreted by the kidneys.

Question 11

I123 NaI Dose & Administration

Answer 11

100-400 uCi

Question 12

Which radiopharmaceutical focuses on the evaluation of Parkinson disease?

Answer 12

I123 Ioflupane

Question 13

Which radiopharmaceutical focuses on metastatic pheochromocytoma or neuroblastoma?

Answer 13

I1234 Iobenguane (AdreView)

Question 14

Which radiopharmaceutical focuses on the thyroid?

Answer 14

I123 NaI