I131

Question 1

What is the half-life of I131?

Answer 1

8 days

Question 2

What are the energies of I131?

Answer 2

365 keV (gamma) & 606 keV (beta minus)

Question 3

I131 AXEDRA Iobenguane

Answer 3

A therapeutic agent used to treat adults and pediatric patients of 12 years old or older with iobenguane positive scan, unresectable, locally advanced, metastatic pheochromocytoma, or paraganglioma who require systemic anticancer therapy.

Question 4

I131 AXEDRA Iobenguane Clinical Pharmaccology

Answer 4

Iobenguane has a similar structure as the neurotransmitter norepinephrine and is subject to the same uptake and accumulation pathways as NE.

Question 5

I131 AXEDRA Iobenguane Dose & Administration

Answer 5

For Diagnostic:
- Patients greater than 50 kg, receives about 5 to 6 mCi.
- Patients 50 kg or less, they receive about 0.1 mCi per kg.
For Therapeutic:
- Patients greater than 62.5 kg, receives about 500 mCi.
- Patients 62.5 kg or less, receives about 8 mCi/kg

Question 6

I131 BEXXAR Tositumomab

Answer 6

: It is a therapeutic regiment used for the treatment of patients with CD20 antigen-expressing relapsed or refractory, low grade, follicular, or transformed non-Hodgkin’s lymphoma, including patients with Rituximab-refractory non-Hodgkin’s lymphoma.

Question 7

I131 BEXXAR Tositumomab Clinical Pharmacology

Answer 7

Tositumomab is a murine IgG2a lambda monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Iodine I 131 Tositumomab is a radio-iodinated derivative of Tositumomab that has been covalently linked to Iodine-131. Possible mechanisms of action of the BEXXAR therapeutic regimen include induction of apoptosis, complement-dependent cytotoxicity, and antibody-dependent cellular cytotoxicity mediated by the antibody

Question 8

I131 BEXXAR Tositumomab Dose & Administration

Answer 8

There are four components of administration in two discrete steps.
The Dosimetric Step:
- Administer about 450 mg of Tositumomab intravenously in 50 mL 0.9% Sodium Chloride over 60 minutes. Administer Iodine I131 Tositumomab, which contains 5 mCi of Iodine-131 and 35 mg of Tositumomab, intravenously in 30 mL 0.9% Sodium Chloride over 20 min.
The Therapeutic Step:
- Administer about 450 mg of Tositumomab intravenously in 50 mL 0.9% Sodium Chloride over 60 minutes. For administer Iodine I131, you need to calculate the dose by determining total body residence time and activity hours.

Question 9

I131 Megatope Albumin

Answer 9

It is a diagnostic agent used for the determination of total blood and plasma volume, cardiac output, cardiac and pulmonary blood volume and circulation times, and in protein turnover studies.

Question 10

I131 Megatope Albumin Clinical Pharmacology

Answer 10

Radioiodinated albumin human is uniformly distributed throughout the intravascular pool within ten min while the extravascular distribution is at a slower pace. It takes about two to four days for the radioactivity to be distributed throughout the extravascular space.

Question 11

I131 Megatope Albumin Dose & Administration

Answer 11

5-500 uCi

Question 12

I131 MIBG

Answer 12

Iobenguane Sulfate I 131 is indicated as an adjunctive diagnostic agent in the localization of primary or metastatic pheochromocytomas and neuroblastomas

Question 13

I131 MIBG Clinical Pharmacology

Answer 13

Iobenguane Sulfate I 131 enters adrenergic neurons and chromaffin cells primarily by thetype I (activetransport) mechanism ofcatecholamine uptake into adrenergic storage granules.

Question 14

I131 MIBG Dose & Administration

Answer 14

Intravenous use, administer about 0.5 mCi. For obese adults over 65 kg, the dose should be 0.3 mCi to 1 mCi. For pediatric use, the recommended dose ranges from 0.135 mCi to 0.5 mCi.

Question 15

I131 NaI Diag Draximage Oral

Answer 15

It is a diagnostic radiopharmaceutical used for an uptake test to evaluate thyroid function.

Question 16

I131 NaI Diag Draximage Oral Clinical Pharmacology

Answer 16

The iodide is primarily distributed within the extra-cellular fluid of the body and it is trapped by the thyroid. Trapped iodide is oxidized to iodine and incorporates so rapidly that the iodide trap of the thyroid contains less than 1 percent of free iodide. This process results in further concentration of iodine in the thyroid gland to about 500 times that in the blood.

Question 17

I131 NaI Diag Draximage Oral Dose & Administration

Answer 17

Oral administration. For thyroid uptake, the dose ranges from 5 uCi to 15 uCi. For imaging, the dose ranges from 50 uCi to 100 uCi.

Question 18

I131 NaI Therapy

Answer 18

It is a therapeutic agent indicated for the treatment of hyperthyroidism and selected cases of carcinoma of the thyroid

Question 19

I131 NaI Therapy Clinical Pharmacolgy

Answer 19

Iodide to actively transporter by the sodium-iodide symporter protein, which is found in the thyroid follicular cells. Iodide is metabolically oxidized by thyroid peroxidase to iodinium, which iodinates tyrosine residues of thyroglobulin. The beta emission of I-131 is responsible for the therapeutic effect

Question 20

I131 NaI Therapy Dose & Administration

Answer 20

Use only by, or under the direction of the physician to administer the capsule. The recommended dose is 4 to 10 mCi. Up to 200 mCi is for thyroid cancer patients.

Question 21

I131 Volumex human serum albumin

Answer 21

A diagnostic radiopharmaceutical used in determinations of total blood and plasma volumes and in protein turnover studies

Question 22

I131 Volumex human serum albumin Clinical Pharmacology

Answer 22

Radioiodinated albumin human is uniformly distributed throughout the intravascular pool within ten min while the extravascular distribution is at a slower pace. It takes about two to four days for the radioactivity to be distributed throughout the extravascular space. By the time the radioactivity has reached maximal activity in the extravascular space, then it has reached its equilibrium time. From there, both the intravascular and extravascular activity spaces will decrease slowly and exponentially

Question 23

I131 Volumex human serum albumin Dose & Administration

Answer 23

It is administered intravenously and the total dosage should not exceed 200 microcuries in any one week. Dosage may range from 5 to 500 microcuries.

Question 24

Which radiopharmaceutical’s treats is Hodgkin’s disease?

Answer 24

I131 Bexxar Tositumomab

Question 25

Which radiopharmaceutical determinds the total blood and plasma volume?

Answer 25

I131 Megatope Albumin

Question 26

Which radiopharmaceutical is a diagnostic agent for pheochromocytomas and neuroblastomas?

Answer 26

I131 MIBG

Question 27

Which radiopharmaceutical evaluate thyroid function?

Answer 27

I131 NaI Diag Draximage Oral

Question 28

Which radiopharmaceutical treats hyperthyroidism?

Answer 28

I131 NaI Therapy

Question 29

Which radiopharmaceutical is diagnose the determinations of total blood and plasma volumes and protein turnover studies?

Answer 29

I131 Volumex human serum albumin