Gallium

Question 1

What is the half life of Ga67?

Answer 1

78.3 hours (3.26 days)

Question 2

What are the energies of Ga67?

Answer 2

93 keV, 184 keV, 300 keV, 393 keV

Question 3

Ga67 Citrate

Answer 3

It is useful to demonstrate the presence and extent of Hodgkin’s disease, lymphoma, and bronchogenic carcinoma.

Question 4

Ga67 Citrate Clinical Pharmacology

Answer 4

It concentrates in certain viable primary and metastatic tumors as well as focal sites of infection. The mechanism is unknown, but it has shown to accumulate in lysosomes and bound to intracellular proteins.

Question 5

Ga67 Citrate Dose & Administration

Answer 5

2 - 8 mCi

Question 6

What is the half-life of Ga68?

Answer 6

68 minutes

Question 7

What are the energies of Ga68?

Answer 7

Positron = 836 keV, 2x511 keV

Question 8

Ga68 Dotatate NETSPOT

Answer 8

A diagnostic agent indicated for localization of somatostatin receptor positive neuroendocrine tumors in adult and pediatrics.

Question 9

Ga68 Dotatate NETSPOT Clinical Pharmacology

Answer 9

Ga 68 dotatate binds to somatostatin receptors, with highest affinity for subtype 2 receptors (sstr2). It binds to cells that express somatostatin receptors including malignant cells, which overexpress sstr2 receptors. Ga 68 dotatate distributes to all sstr2-expressing organs such as pituitary, thyroid, spleen, adrenals, kidney, pancreas, prostate, liver, and salivary glands.

Question 10

Ga68 Dotatate NETSPOT Dose & Administration

Answer 10

2 MBq/kg of body weight (0.054 mCi/kg) up to 200 MBq (5.4 mCi)

Question 11

Ga68 Dotatoc PI

Answer 11

A diagnostic agent indicated for localization of somatostatin receptor positive neuroendocrine tumors in adult and pediatrics.

Question 12

Ga68 Dotatoc PI Clinical Pharmacology

Answer 12

Ga 68 dotatate binds to somatostatin receptors, with highest affinity for subtype 2 receptors (sstr2). It binds to cells that express somatostatin receptors including malignant cells, which overexpress sstr2 receptors. Ga 68 dotatate distributes to all sstr2-expressing organs such as pituitary, thyroid, spleen, adrenals, kidney, pancreas, prostate, liver, and salivary glands.

Question 13

Ga68 Dotatoc PI Dose & Administration

Answer 13

3 mCi - 5 mCi thru IV for adults

0.3 mCi - 3mCi thru IV for pediatrics

Question 14

Which radiopharmaceutical has the highest concentration in the renal cortex?

Answer 14

Ga67 Citrate

Question 15

Which radiopharmaceutical focuses on neuroendocrine tumors?

Answer 15

Ga68

Question 16

Which group of receptors does Ga68 radiopharmaceutical bind to?

Answer 16

somatostatin

Question 17

Although Ga67 has an unknown mechanism, most studies have show that its found mostly in?

Answer 17

lysosomes

Question 18

What does Ga67 demonstrate?

Answer 18

the presence of hodgkin’s disease, lymphoma, and bronchogenic carcinoma.