Carbon

Question 1

What is the half life of Carbon 11?

Answer 1

20.4 min

Question 2

What are the energies for Carbon 11?

Answer 2

Positron = 960 keV and Gamma = 511keV

Question 3

What is C11 brand name?

Answer 3

Choline

Question 4

C11 Choline

Answer 4

PET tracer for imaging of patients with suspected prostate cancer recurrence and non-informative bone scintigraphy. It hleps identifies potential sites of prostate cancer recurrence for subsequent histologic confimation.

Question 5

C11 Choline Clinical Pharmacology

Answer 5

Choline C 11 Injection is a radiolabeled analog of choline, a precursor molecule essential for the biosynthesis of cell membrane phospholipids. Choline is involved in synthesis of the structural components of cell membranes, as well as modulation of trans-membrane signaling. Increased phospholipid synthesis (i.e., increased uptake of choline) has been associated with cell proliferation.

Question 6

C11 Choline Clinical Dose & Administration

Answer 6

10-20 mCi through a bolus IV injection.

Question 7

What is the half life of Carbon 14?

Answer 7

5730 years

Question 8

What are the energies of Carbon 14?

Answer 8

beta emission = 49 keV and 156 keV

Question 9

What is the brand name for Carbon 14?

Answer 9

C14 H. Pylori

Question 10

C14 H. Pylori Clinical Pharmacology

Answer 10

The urease enzyme is not present in mammalian cells, so the presence of urease in the stomach is evidence that bacteria are present. The presence of urease is not specific for H. pylori, but other bacteria are
not usually found in the stomach.
To detect H. pylori, urea labeled with 14C is swallowed by the patient. If gastric urease from H. pylori is present, urea is split to form CO2 and NH3 at the interface between the gastric epithelium and lumen and 14CO2 is absorbed into the blood and exhaled in the breath.
Following ingestion of the capsule by a patient with H. pylori, 14CO2 excretion in the breath

Question 11

C14 H. Pylori Dose and Administration

Answer 11

a gelatin capsule that contain 1uCi of 14C labeled urea, which absorbed on sugar spheres and colored yellow with fluorescin.

Question 12

Which carbon radiopharmaceuitcal uses a breath test?

Answer 12

C14 H. Pylori

Question 13

Which carbon radiopharmaceutical identifies potential sites of prostate cancer recurrence?

Answer 13

C11 Choline

Question 14

Which radiopharmaceutical is no longer being used?

Answer 14

C14 H. Pylori