R5 - Male Reproduction

Question 1

____ germ cells migrate to gonadal ridge

Answer 1

Primordial

Question 2

Identification of gonad as testes occurs between ___ weeks gestation

Answer 2

6-7

Question 3

____ expression of Y-chromosome

Answer 3

SRY

Question 4

Sertoli cells —> _____ hormone

Answer 4

anti-mullerian hormone

Question 5

T stimulates mesonephric ducts —-> _____

Answer 5

vas, seminal vesicles and epididymis

Question 6

Primary site of testosterone (T) production

Answer 6

Leydig cells

Question 7

-Fetal Leydig cells function is LH ____
-Adult Leydig cells function is LH ____

Answer 7

-independent
-dependent

Question 8

LH is secreted from the pituitary in response to ____

Answer 8

GnRH
-Binds to LH receptors on Leydig cells to stimulate testosterone production

Question 9

Circulating LDL provides source for _____ precursor

Answer 9

cholesterol

Question 10

Sertoli cells

Answer 10

• Blood-testisbarrier
• Spermatogensis
• Male phenotypic development
• HPG axis balance

Question 11

Required for spermatogenesis = ____ binds to Sertoli cell receptor and stimulates protein synthesis and aromatase activity

Answer 11

FSH

Question 12

Spermatogenesis process

Answer 12

• LH binds to Leydig cell = stimulate T
• Testosterone diffuses into Sertoli cell
• Testosterone augments spermatogenesis
• FSH binds to Sertoli cell receptor to stimulate spermatogenesis and inhibin production

Question 13

Role of Inhibin

Answer 13

-Locally (paracrine) to increase LH stimulated testosterone production
-Pituitary (endocrine) to decrease FSH release

Question 14

____ is acquired in the epididymis, therefore sperm within the seminiferous tubule are _____

Answer 14

-Motility
-non motile

Question 15

Spermatogenesis requires ____ temperature

Answer 15

Cooler
-Endocrine function of testes is not temperature sensitive
-Conditions increase testicular temp can decrease fertility

Question 16

Semen analysis

Answer 16

• Lab matters
• Abstinence for 2-4days
• 2 good collections