Grace's Endo

Question 1

-Primary:
-Secondary:
-Tertiary:

Answer 1

-Gland dysfunction
-Pituitary dysfunction
-Hypothalamic dysfunction

Question 2

-Hypothalamus:
-Anterior:

Answer 2

-“Releasing hormone”
-“Troph” then “Hormone” (acth/lh/tsh)

Question 3

ADH deficit

Answer 3

Diabetes insipidus
-Increase Na, Posm
-Decrease Uosm
-Polyuria

**Desmopressin for central

Question 4

ADH excess

Answer 4

SIADH
-Decrease Na, Posm
-Increase Uosm
-Olvaptan

Question 5

Thyroid
-Increased binding caused by ___
-Decreased binding caused by ___

Answer 5

-Estrogens

-Androgens, ICs, protein deficiency

Question 6

Goiters caused by stimulation of ____

Answer 6

TSH receptor (iodine deficiency, Grave’s)

Question 7

Hypothyroidism

Answer 7

Chills, tired, weight gain

-Levo (T4), take on ES
-Lio (T3), fast onset

Question 8

Hyperthyroidism

Answer 8

Hot, weight loss, nervous (Grave’s)

-PTU: for preg/lactating
-Meth: excreted in BM/P

Question 9

Addison’s (hypo, adrenal)

Answer 9

Autoimmune
-Congenital adrenal hyperplasia (21-hydrox def)
-Increase 17-OH progesterone (diagnostic)

Question 10

Cushing’s (hyper, adrenal)

Answer 10

Tumors, chronic GC therapy
-Dexamethasone suppression test
-Aldo excess only, 17-OH def

Question 11

Synthetic Corticosteroids

Answer 11

Use for hypo conditions
-AE: Cushing’s sx
-DDI: NSAIDS, diabetes meds, diuretics/digoxin, HTN meds, CYP, live vaccines

Question 12

Gonadal
-Androgens:
-Estradiol:
-Progesterone:

Answer 12

-testicular leydig cells

-theca cells make ASD

-luteal cells

Question 13

Hyperprolactinemia

Answer 13

High PRL, low LH/FSH or es/test

HA, vision prob

TX: DA agonist, tumor removal