M7 - Pentose Phosphate Shunt Flashcards

1
Q

___ cells express the pentose phosphate shunt

A

ALL

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2
Q

Branchpoint intermediate can =

A

= ribose 5 P
or
= re-enter glycolysis

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3
Q

The first and rate-limiting enzyme of the pentose shunt is _____, which generates one of the NADPH molecules

A

glucose-6-phosphate dehydrogenase (G6PD)

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4
Q

NADPH Functions

A
  1. Lipid synthesis, e.g.:
    a. Fatty acids (FA)
    b. Cholesterol (C)
    c. Steroid hormones
    d. Bile acids
  2. Maintains gluta- thione in a reduced form (“GSH”) to act as an anti-oxidant
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5
Q

Ribose-5-P Function

A

Nucleotide synthesis

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6
Q

All cells EXCEPT ____ synthesize RNA and DNA in their nuclei

A

RBCs

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7
Q

All cells use ____ to maintain glutathione as an anti-oxidant

A

NADPH

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8
Q

Pentose shunt generates most of the ____ needed to maintain GSH for the rest of cell

A

NADPH

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9
Q

____ require NADPH from pentose shunt to prevent excessive hemolysis (and anemia)

A

RBCs

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