M7 - Pentose Phosphate Shunt Flashcards
1
Q
___ cells express the pentose phosphate shunt
A
ALL
2
Q
Branchpoint intermediate can =
A
= ribose 5 P
or
= re-enter glycolysis
3
Q
The first and rate-limiting enzyme of the pentose shunt is _____, which generates one of the NADPH molecules
A
glucose-6-phosphate dehydrogenase (G6PD)
4
Q
NADPH Functions
A
- Lipid synthesis, e.g.:
a. Fatty acids (FA)
b. Cholesterol (C)
c. Steroid hormones
d. Bile acids - Maintains gluta- thione in a reduced form (“GSH”) to act as an anti-oxidant
5
Q
Ribose-5-P Function
A
Nucleotide synthesis
6
Q
All cells EXCEPT ____ synthesize RNA and DNA in their nuclei
A
RBCs
7
Q
All cells use ____ to maintain glutathione as an anti-oxidant
A
NADPH
8
Q
Pentose shunt generates most of the ____ needed to maintain GSH for the rest of cell
A
NADPH
9
Q
____ require NADPH from pentose shunt to prevent excessive hemolysis (and anemia)
A
RBCs