Quizzes 2 And 3 Flashcards
Which of the following glial cells are important in synaptic pruning during brain development?
Microglial cells
Which of the following proteins is shown to be associated with the excess production of synapses in autism patients?
MTOR
Which of the following statements is false?
A. Methylmercury can cross the blood-brain barrier as a Methylmercury-amino acid complex
B. Dental amalgam is made of liquid mercury and a powder containing silver, tin, copper, zinc, and other metals
C. Mercury can directly affect the neurotransmitters and the destruction of the structural framework of neurons
D. Inorganic mercury cannot cross the blood-brain barrier of the developing brain
D. Inorganic mercury cannot cross the blood-brain barrier of the developing brain
It can pass, just very slowly
Which one of the proteins is a synaptic cell-adhesion protein that connects presynaptic and postsynaptic neurons at synapses?
Neurexins
which of the following is not an apoptotic protein?
A. Bcl-2
B. Bad
C. BAX
D. BIM
A. Bcl-2
Which one of the following autism spectrum disorders is characterized by a rare genetic neurological disorder affecting brain development?
Rhett’s disorder
Mitochondrial fission and fusion proteins are known to be altered in autism brain. Which one of the following is the mitochondrial fission protein?
Drp1
True or False: Gestational exposure to particulate matter causes the decrease in the expression of caspases, especially the regulation of the inflammatory cytokines in hippocampus.
False (increase caspase expression would lead to apoptosis, and PM exposure increases apoptosis)
Which one of the following statements is not true in affecting brain development with lead exposure?
A. Excitotoxicity
B. Apoptosis
C. Adverse affects of glial cells
D. Less ROS formation
D. Less ROS formation
(it would be much more ROS formation if it were true)
Which of the following is true in the involvement of sonic Hedgehog (SHH) during brain development?
A. Cellular proliferation
B. Epigenetic modification
C. Cytokines production
D. Myelination
A. Cellular proliferation
Which one of the following neurotransmitters is used by cholinergic neurons in the central nervous system?
Acetylcholine
True or False: Mushroom spines have mostly smaller heads that are involved in synaptic transmission important in learning and memory functions.
False
Mitochondrial dysfunction in autism spectrum disorders is associated with:
A. impairments in electron transport complexes
B. oxidative stress and reactive oxygen species
C. mutations in mitochondrial DNA
D. All of the above
D. All of the above
True or False: the epigenetic modifications in individuals with autism are shown to have DNA methylation. this process adds a -CH3 group to the segment of DNA that affects the function of the gene involved in autism
True
which of the following factors is true in determining the health effects of mercury?
A. the age the person exposed
B. the route of exposure
C. the chemical form and the dose
D. All of the above
D. All of the above
Which of the following mitochondrial proteins is not required caspases for causing the apoptosis?
A. Cytochrome C
B. smac
C. Endonuclease G
D. None of the above
D. None of the above
True or False: in apoptosis, the inflamed and swollen cells lyses and ingested by macrophages
False
Which one of the Bcl-2 family members is shown to be unregulated during the development of early embryogenesis?
MCL-1
True or false: In the developing brain, during the synaptogenesis, the entry of calcium ions through the NMDA receptor play a critical role in cellular mechanisms for learning and memory.
True
True or False: The Bcl-2 family memberss Bcl-2 and Bcl-XL are shown the release several mitochondrial apoptosis proteins including Cytochrome C.
False (Bax and Bak do)
which one of the following is the initiator caspases in the execution of extrinsic apoptosis?
Caspase 8
Which of the following is false?
A. Mercury has toxic effects on the nervous and immune systems
B. Exposure to small amounts of mercury is not a threat to the development of the child in utero and early in life
C. When mercury deposits into lakes and rivers, it is converted to methyl mercury by the methylating activity of sulphate reducing bacteria
D. Methylmercury enters the aquatic food chin and bioaccumulates in fish and sea mammals
B
True or False: Mercury, a transition metal, is less reactive than alkali metals with a bad conductor of heat.
False: mercury and other transition metals are generally good conductors
True or False: apoptosis causes no fragmentation of nucleus while necrosis is associated with chromatin condensation and DNA Fragmentation
False: Apoptosis is associated with fragmentation of nucleus AND chromatin condensation and DNA fragmentation